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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Receptor-type tyrosine-protein kinase FLT3 | ||
| Ligand | BDBM350857 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 1.70±n/a nM | ||
| Citation |  Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity US Patent US10004755 Publication Date 6/26/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Receptor-type tyrosine-protein kinase FLT3 | |||
| Name: | Receptor-type tyrosine-protein kinase FLT3 | ||
| Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 112888.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36888 | ||
| Residue: | 993 | ||
| Sequence: |
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| BDBM350857 | |||
| n/a | |||
| Name | BDBM350857 | ||
| Synonyms: | UNC2253A | US10004755, Compound UNC2253A | US9795606, B16 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H39N5O2 | ||
| Mol. Mass. | 489.6523 | ||
| SMILES | CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1(CC1)N1CCOCC1 |r,wU:11.11,wD:15.15,(-8.43,-2.68,;-7.1,-1.91,;-5.76,-2.68,;-4.43,-1.91,;-3.09,-2.68,;-1.76,-1.91,;-1.76,-.37,;-.43,.4,;.91,-.37,;2.37,.1,;3.28,-1.14,;2.37,-2.39,;2.77,-3.88,;4.26,-4.27,;4.66,-5.76,;3.57,-6.85,;3.97,-8.34,;2.08,-6.45,;1.68,-4.96,;.91,-1.91,;-.43,-2.68,;2.77,1.59,;4.26,1.99,;4.66,3.48,;3.57,4.57,;2.08,4.17,;1.68,2.68,;3.97,6.05,;3.57,7.54,;2.48,6.45,;5.45,6.45,;6.54,5.36,;8.03,5.76,;8.43,7.25,;7.34,8.34,;5.85,7.94,)| | ||
| Structure | 
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