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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Receptor-type tyrosine-protein kinase FLT3 | ||
| Ligand | BDBM401013 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 2.00±n/a nM | ||
| Citation |  Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity US Patent US10004755 Publication Date 6/26/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Receptor-type tyrosine-protein kinase FLT3 | |||
| Name: | Receptor-type tyrosine-protein kinase FLT3 | ||
| Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 112888.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36888 | ||
| Residue: | 993 | ||
| Sequence: |
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| BDBM401013 | |||
| n/a | |||
| Name | BDBM401013 | ||
| Synonyms: | US10004755, Compound UNC4319A | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H40N6O | ||
| Mol. Mass. | 476.6568 | ||
| SMILES | CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC2CCCNCC2)cc1 |r,wD:15.15,(-8.67,-2.82,;-7.34,-2.05,;-6,-2.82,;-4.67,-2.05,;-3.34,-2.82,;-2,-2.05,;-2,-.51,;-.67,.26,;.66,-.51,;2.13,-.04,;3.03,-1.28,;2.13,-2.53,;2.53,-4.02,;4.02,-4.42,;4.41,-5.9,;3.32,-6.99,;3.72,-8.48,;1.84,-6.59,;1.44,-5.11,;.66,-2.05,;-.67,-2.82,;2.53,1.45,;4.02,1.85,;4.41,3.34,;3.32,4.42,;3.72,5.91,;5.21,6.31,;5.55,7.81,;6.94,8.48,;8.33,7.81,;8.67,6.31,;7.71,5.11,;6.17,5.11,;1.84,4.03,;1.44,2.54,)| | ||
| Structure | 
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