| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Epithelial discoidin domain-containing receptor 1 |
|---|
| Ligand | BDBM401187 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | LanthaScreen Assay |
|---|
| IC50 | 14.0±n/a nM |
|---|
| Citation |  Murata, T; Hara, S; Niizuma, S; Hada, K; Kawada, H; Sakaitani, M; Shimada, H; Nakanishi, Y Quinazolinone and isoquinolinone derivative US Patent US10005739 Publication Date 6/26/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Epithelial discoidin domain-containing receptor 1 |
|---|
| Name: | Epithelial discoidin domain-containing receptor 1 |
|---|
| Synonyms: | CAK | DDR1 | DDR1_HUMAN | Discoidin domain receptor 1 (DDR1) | Discoidin domain-containing receptor 1 (DDR1) | Discoidin receptor tyrosine kinase | EDDR1 | Epithelial discoidin domain receptor 1 | Epithelial discoidin domain receptor 1 (DDR1) | Epithelial discoidin domain-containing receptor 1 | Epithelial discoidin domain-containing receptor 1 (DDR1) | HGK2 | Mammary carcinoma kinase 10 | NEP | NTRK4 | PTK3A | Protein-tyrosine kinase RTK 6 | RTK6 | TRKE | Tyrosine-protein kinase CAK |
|---|
| Type: | Tyrosine-protein kinase |
|---|
| Mol. Mass.: | 101130.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q08345 |
|---|
| Residue: | 913 |
|---|
| Sequence: | MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR
HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL
RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV
ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD
FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG
VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS
EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI
GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE
PPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNT
QAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP
PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD
ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED
KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI
KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC
RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ
LHRFLAEDALNTV
|
|
|
|---|
| BDBM401187 |
|---|
| n/a |
|---|
| Name | BDBM401187 |
|---|
| Synonyms: | 8-Chloro-3-[(5-chloro-2-ethylsulfonylphenyl)methyl]-7-[[(3R)-3-(dimethylamino)piperidin-1-yl]methyl]-6-(trifluoromethyl)quinazolin-4-one | US10005739, Example 592 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H29Cl2F3N4O3S |
|---|
| Mol. Mass. | 605.5 |
|---|
| SMILES | CCS(=O)(=O)c1ccc(Cl)cc1Cn1cnc2c(Cl)c(CN3CCC[C@H](C3)N(C)C)c(cc2c1=O)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
