| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase III subunit tau |
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| Ligand | BDBM36324 |
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| Substrate/Competitor | BDBM50118233 |
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| Meas. Tech. | colorimetric ATPase assay |
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| pH | 7.5±0 |
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| Temperature | 310.15±0 K |
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| Ki | 8.1e+3± 2.3e+3 nM |
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| Citation |  Eng, K; Scouten-Ponticelli, SK; Sutton, M; Berdis, A Selective Inhibition of DNA Replicase Assembly by a Non-natural Nucleotide: Exploiting the Structural Diversity of ATP-Binding Sites ACS Chem Biol5:183-94 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| DNA polymerase III subunit tau |
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| Name: | DNA polymerase III subunit tau |
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| Synonyms: | ATP-dependent clamp loader gamma -complex | DNA polymerase III subunit gamma | DPO3X_ECOLI | dnaX | dnaZ | dnaZX |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71139.93 |
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| Organism: | Escherichia coli |
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| Description: | P06710 |
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| Residue: | 643 |
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| Sequence: | MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAK
GLNCETGITATPCGVCDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRF
KVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKALDV
EQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM
LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPA
ALGNDMAAIELRMRELARTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFH
PRMPLPEPEVPRQSFAPVAPTAVMTPTQVPPQPQSAPQQAPTVPLPETTSQVLAARQQLQ
RVQGATKAKKSEPAAATRARPVNNAALERLASVTDRVQARPVPSALEKAPAKKEAYRWKA
TTPVMQQKEVVATPKALKKALEHEKTPELAAKLAAEAIERDPWAAQVSQLSLPKLVEQVA
LNAWKEESDNAVCLHLRSSQRHLNNRGAQQKLAEALSMLKGSTVELTIVEDDNPAVRTPL
EWRQAIYEEKLAQARESIIADNNIQTLRRFFDAELDEESIRPI
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| BDBM36324 |
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| BDBM50118233 |
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| Name | BDBM36324 |
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| Synonyms: | 6-nitro-indolyl- 2'-deoxyriboside triphosphate | d6-NITP |
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| Type | Small organic molecule |
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| Emp. Form. | C13H17N2O14P3 |
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| Mol. Mass. | 518.2004 |
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| SMILES | [H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2ccc(cc12)[N+]([O-])=O |
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| Structure | 
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