| Reaction Details |
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 | Report a problem with these data |
| Target | Complex of Sliding-clamp-loader large subunit [R175L] and Sliding-clamp-loader small subunit |
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| Ligand | BDBM36316 |
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| Substrate/Competitor | BDBM50118233 |
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| Meas. Tech. | colorimetric ATPase assay |
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| pH | 7.5±0 |
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| Temperature | 298.15±0 K |
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| Ki | 1.10e+4± 3.5e+3 nM |
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| Citation |  Eng, K; Scouten-Ponticelli, SK; Sutton, M; Berdis, A Selective Inhibition of DNA Replicase Assembly by a Non-natural Nucleotide: Exploiting the Structural Diversity of ATP-Binding Sites ACS Chem Biol5:183-94 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Complex of Sliding-clamp-loader large subunit [R175L] and Sliding-clamp-loader small subunit |
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| Name: | Complex of Sliding-clamp-loader large subunit [R175L] and Sliding-clamp-loader small subunit |
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| Synonyms: | ATP-dependent clamp loaders gp44/62 (R175L) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57093.31 |
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| Organism: | bacteriophage T4 |
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| Description: | Modified from ATP-dependent clamp loaders 44/62 |
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| Residue: | 506 |
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| Sequence: | MITVNEKEHILEQKYRPSTIDECILPAFDKETFKSITSKGKIPHIILHSPSPGTGKTTVA
KALCHDVNADMMFVNGSDCKIDFVRGPLTNFASAASFDGRQKVIVIDEFDRSGLAESQRH
LRSFMEAYSSNCSIIITANNIDGIIKPLQSRCRVITFGQPTDEDKIEMMKQMIRLLTEIC
KHEGIAIADMKVVAALVKKNFPDFRKTIGELDSYSSKGVLDAGILSLVTNDRGAIDDVLE
SLKNKDVKQLRALAPKYAADYSWFVGKLAEEIYSRVTPQSIIRMYEIVGENNQYHGIAAN
TELHLAYLFIQLACEMQWKMSLFKDDIQLNEHQVAWYSKDWTAVQSAADSFKEKAENEFF
EIIGAINNKTKCSIAQKDYSKFMVENALSQFPECMPAVYAMNLIGSGLSDEAHFNYLMAA
VPRGKRYGKWAKLVEDSTEVLIIKLLAKRYQVNTNDAINYKSILTKNGKLPLVLKELKGL
VTDDFLKEVTKNVKEQKQLKKLALEW
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| BDBM36316 |
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| BDBM50118233 |
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| Name | BDBM36316 |
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| Synonyms: | 5-ethyl-indolyl- 2'-deoxyriboside triphosphate | d5-EtITP |
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| Type | Small organic molecule |
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| Emp. Form. | C15H22NO12P3 |
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| Mol. Mass. | 501.256 |
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| SMILES | [H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2cc(CC)ccc12 |
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| Structure | 
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