| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK1 |
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| Ligand | BDBM8055 |
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| Substrate/Competitor | Cdc25C |
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| Meas. Tech. | Drosophilia melanogaster kinase assay |
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| pH | 7.5±0 |
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| Temperature | 293.15±0 K |
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| IC50 | 2.5e+4±n/a nM |
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| Citation |  McInnes, C; Mazumdar, A; Mezna, M; Meades, C; Midgley, C; Scaerou, F; Carpenter, L; Mackenzie, M; Taylor, P; Walkinshaw, M; Fischer, PM; Glover, D Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol2:608-17 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Serine/threonine-protein kinase PLK1 |
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| Name: | Serine/threonine-protein kinase PLK1 |
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| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 68277.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53350 |
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| Residue: | 603 |
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| Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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| BDBM8055 |
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| Cdc25C |
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| Name: | M-phase inducer phosphatase 3 |
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| Synonyms: | CDC25C | Dual specificity phosphatase Cdc25C | M-phase inducer phosphatase 3 | MPIP3_HUMAN |
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| Type: | Substrate |
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| Mol. Mass.: | 53366.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30307 |
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| Residue: | 473 |
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| Sequence: | MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANL
SILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMK
CSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNP
NLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDK
VKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQ
DLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKK
PIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFF
PEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP
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