| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipase D1 |
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| Ligand | BDBM50206160 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | d.311 Enzymatic Inhibition Assay |
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| Temperature | 310.15±0 K |
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| IC50 | 11±0.0 nM |
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| Citation |  Scott, SA; Selvy, PE; Buck, JR; Cho, HP; Criswell, TL; Thomas, AL; Armstrong, MD; Arteaga, CL; Lindsley, CW; Brown, HA Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol5:108-17 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Phospholipase D1 |
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| Name: | Phospholipase D1 |
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| Synonyms: | Choline phosphatase 1 | PLD 1 | PLD1 | PLD1_HUMAN | Phosphatidylcholine-hydrolyzing phospholipase D1 | Phospholipase D (PLD) | Phospholipase D1 | Phospholipase D1 (PLD1) | Phospholipase D2 (PLD2) | hPLD1 |
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| Type: | Protein |
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| Mol. Mass.: | 124219.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13393 |
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| Residue: | 1074 |
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| Sequence: | MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSA
IYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKF
KHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRR
KQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNC
CGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRID
NLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKG
YFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLY
KEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGI
DLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKS
IDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGL
KPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQL
DKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLL
PKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIE
NQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQ
AIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLL
IADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCF
RVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFI
NKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT
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| BDBM50206160 |
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| n/a |
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| Name | BDBM50206160 |
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| Synonyms: | CHEMBL245621 | Halopemide | Halopemide, 8 | N-(2-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-4-fluorobenzamide | N-(2-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-4-fluorobenzamide | cid_65490 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22ClFN4O2 |
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| Mol. Mass. | 416.876 |
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| SMILES | Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O |
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| Structure | 
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