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Compile Data Set for Download or QSAR

Found 420 hits with Last Name = 'brown' and Initial = 'ha'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phospholipase D1


(Homo sapiens (Human))		BDBM36423
PNG
(4-Methyl-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imi...)
Show SMILES Cc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C22H26N4O2/c1-16-6-8-17(9-7-16)21(27)23-12-15-25-13-10-18(11-14-25)26-20-5-3-2-4-19(20)24-22(26)28/h2-9,18H,10-15H2,1H3,(H,23,27)(H,24,28)
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n/an/a 1.70n/an/an/an/an/a37



Vanderbilt University



Assay Description
Phopholipase D1(PLD)enzymatic inhibition assay using PLD1.d311

Nat Chem Biol 5: 108-17 (2009)


Article DOI: 10.1038/nchembio.140
BindingDB Entry DOI: 10.7270/Q2D50KBK
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50257542
PNG
((S)-N-(1-(4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C26H27FN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-15-21(27)8-9-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50423651
PNG
(CHEMBL2304616)
Show SMILES Clc1ccc2n(C3CCN(CCNC(=O)C4C[C@@H]4c4ccccc4)CC3)c(=O)[nH]c2c1 |r|
Show InChI InChI=1S/C24H27ClN4O2/c25-17-6-7-22-21(14-17)27-24(31)29(22)18-8-11-28(12-9-18)13-10-26-23(30)20-15-19(20)16-4-2-1-3-5-16/h1-7,14,18-20H,8-13,15H2,(H,26,30)(H,27,31)/t19-,20?/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50257530
PNG
((S)-N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C22H23ClF2N4O2/c1-13(26-21(30)14-2-4-17(24)18(25)10-14)12-28-8-6-16(7-9-28)29-20-5-3-15(23)11-19(20)27-22(29)31/h2-5,10-11,13,16H,6-9,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258131
PNG
(CHEMBL492561 | N-(2-(4-(5-bromo-2-oxo-2,3-dihydro-...)
Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O
Show InChI InChI=1S/C21H22BrClN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50257531
PNG
((S)-N-(1-(4-(5-bromo-2-oxo-2,3-dihydro-1H-benzo[d]...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C22H23BrF2N4O2/c1-13(26-21(30)14-2-4-17(24)18(25)10-14)12-28-8-6-16(7-9-28)29-20-5-3-15(23)11-19(20)27-22(29)31/h2-5,10-11,13,16H,6-9,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50257541
PNG
((1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C25H29BrN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM87119
PNG
((1R,2R)-N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidaz...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C25H29BrN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



Vanderbilt University



Assay Description
Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...

ACS Chem Biol 10: 421-32 (2015)


Article DOI: 10.1021/cb500828m
BindingDB Entry DOI: 10.7270/Q2H70DK8
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258128
PNG
(CHEMBL493010 | N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro...)
Show SMILES Fc1ccc2n(C3CCN(CCNC(=O)c4ccc5ccccc5c4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C25H25FN4O2/c26-20-7-8-23-22(16-20)28-25(32)30(23)21-9-12-29(13-10-21)14-11-27-24(31)19-6-5-17-3-1-2-4-18(17)15-19/h1-8,15-16,21H,9-14H2,(H,27,31)(H,28,32)
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n/an/a 4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258179
PNG
(CHEMBL521990 | N-(2-(4-(5-bromo-2-oxo-2,3-dihydro-...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O
Show InChI InChI=1S/C21H22BrFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258181
PNG
(3,4-difluoro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1...)
Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CCNC(=O)c4ccc(F)c(F)c4)CC3)c2c1
Show InChI InChI=1S/C21H21F3N4O2/c22-14-2-4-18-19(12-14)28(21(30)26-18)15-5-8-27(9-6-15)10-7-25-20(29)13-1-3-16(23)17(24)11-13/h1-4,11-12,15H,5-10H2,(H,25,29)(H,26,30)
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n/an/a 4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50257540
PNG
((S)-N-(1-(4-(5-bromo-2-oxo-2,3-dihydro-1H-benzo[d]...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H24BrClN4O2/c1-14(25-21(29)15-2-5-17(24)6-3-15)13-27-10-8-18(9-11-27)28-20-7-4-16(23)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50257581
PNG
((S)-N-(1-(4-(5-bromo-2-oxo-2,3-dihydro-1H-benzo[d]...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C26H27BrN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1
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n/an/a 5.5n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50427800
PNG
(CHEMBL2325485)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(C)c1)NC(=O)c1ccc(Br)cc1 |r|
Show InChI InChI=1S/C24H29BrN4O2/c1-17-4-3-5-21(14-17)29-16-26-23(31)24(29)10-12-28(13-11-24)15-18(2)27-22(30)19-6-8-20(25)9-7-19/h3-9,14,18H,10-13,15-16H2,1-2H3,(H,26,31)(H,27,30)/t18-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of PLD1 in human Calu-1 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition measured af...

J Med Chem 56: 2695-9 (2013)


Article DOI: 10.1021/jm301782e
BindingDB Entry DOI: 10.7270/Q2RJ4KT8
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50039461
PNG
(CHEMBL3357311)
Show SMILES CC(CNC(=O)c1cc2ccccc2[nH]1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
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n/an/a 6n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of PLD2 (unknown origin) expressed in HEK293-gfp cells by cell-based assay

Bioorg Med Chem Lett 24: 5553-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.017
BindingDB Entry DOI: 10.7270/Q20R9R15
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM154517
PNG
(ML299 (5))
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C23H26BrFN4O2/c1-16(27-21(30)17-5-7-18(24)8-6-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)20-4-2-3-19(25)13-20/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1
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n/an/a 6.10n/an/an/an/an/an/a



Vanderbilt University



Assay Description
Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...

ACS Chem Biol 10: 421-32 (2015)


Article DOI: 10.1021/cb500828m
BindingDB Entry DOI: 10.7270/Q2H70DK8
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50257528
PNG
((S)-4-chloro-N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-7-6-17(24)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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n/an/a 6.40n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50206160
PNG
(CHEMBL245621 | Halopemide | Halopemide, 8 | N-(2-(...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C21H22ClFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 7n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of dopamine receptor D2 (unknown origin)

J Med Chem 56: 2695-9 (2013)


Article DOI: 10.1021/jm301782e
BindingDB Entry DOI: 10.7270/Q2RJ4KT8
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258180
PNG
(4-chloro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1H-be...)
Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CCNC(=O)c4ccc(Cl)cc4)CC3)c2c1
Show InChI InChI=1S/C21H22ClFN4O2/c22-15-3-1-14(2-4-15)20(28)24-9-12-26-10-7-17(8-11-26)27-19-13-16(23)5-6-18(19)25-21(27)29/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 7n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258263
PNG
((S)-4-chloro-N-(1-(4-(5-fluoro-2-oxo-2,3-dihydro-1...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(F)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H24ClFN4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-7-6-17(24)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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n/an/a 7.40n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50257529
PNG
(CHEMBL521677 | racemic trans-N-((S)-1-(4-(5-chloro...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C25H29ClN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50206153
PNG
(CHEMBL246032 | N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo...)
Show SMILES O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1cnc2ccccc2c1
Show InChI InChI=1S/C24H25N5O2/c30-23(18-15-17-5-1-2-6-20(17)26-16-18)25-11-14-28-12-9-19(10-13-28)29-22-8-4-3-7-21(22)27-24(29)31/h1-8,15-16,19H,9-14H2,(H,25,30)(H,27,31)
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n/an/a 8n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM123744
PNG
(5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imi...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C23H24FN5O2/c24-16-5-6-18-15(13-16)14-20(26-18)22(30)25-9-12-28-10-7-17(8-11-28)29-21-4-2-1-3-19(21)27-23(29)31/h1-6,13-14,17,26H,7-12H2,(H,25,30)(H,27,31)
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n/an/a 9.5n/an/an/an/an/a37



Vanderbilt University



Assay Description
PLD in vitro enzymatic assay using phospholipase D1(PLD1).

Nat Chem Biol 5: 108-17 (2009)


Article DOI: 10.1038/nchembio.140
BindingDB Entry DOI: 10.7270/Q2D50KBK
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258083
PNG
(CHEMBL494183 | N-(2-(4-(5-chloro-2-oxo-2,3-dihydro...)
Show SMILES Cc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C22H25ClN4O2/c1-15-2-4-16(5-3-15)21(28)24-10-13-26-11-8-18(9-12-26)27-20-7-6-17(23)14-19(20)25-22(27)29/h2-7,14,18H,8-13H2,1H3,(H,24,28)(H,25,29)
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n/an/a 10n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258264
PNG
((S)-N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H24ClFN4O2/c1-14(25-21(29)15-2-5-17(24)6-3-15)13-27-10-8-18(9-11-27)28-20-7-4-16(23)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50326960
PNG
((S)-N-(1-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspi...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C27H29FN4O2/c1-19(30-25(33)22-10-9-20-5-2-3-6-21(20)15-22)17-31-13-11-27(12-14-31)26(34)29-18-32(27)24-8-4-7-23(28)16-24/h2-10,15-16,19H,11-14,17-18H2,1H3,(H,29,34)(H,30,33)/t19-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of PLD1 in human calu1 cells

J Med Chem 53: 6706-19 (2010)


Article DOI: 10.1021/jm100814g
BindingDB Entry DOI: 10.7270/Q2XW4K1Z
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50206160
PNG
(CHEMBL245621 | Halopemide | Halopemide, 8 | N-(2-(...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C21H22ClFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 11n/an/an/an/an/a37



Vanderbilt University



Assay Description
Phopholipase D1(PLD)enzymatic inhibition assay using PLD1.d311

Nat Chem Biol 5: 108-17 (2009)


Article DOI: 10.1038/nchembio.140
BindingDB Entry DOI: 10.7270/Q2D50KBK
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258182
PNG
((S)-N-(1-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C26H27ClN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of PLD1 in human calu1 cells

J Med Chem 53: 6706-19 (2010)


Article DOI: 10.1021/jm100814g
BindingDB Entry DOI: 10.7270/Q2XW4K1Z
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258262
PNG
((S)-4-fluoro-N-(1-(4-(5-fluoro-2-oxo-2,3-dihydro-1...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(F)cc2[nH]c1=O)NC(=O)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H24F2N4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-7-6-17(24)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258130
PNG
(4-fluoro-N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro-1H-be...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(F)cc2[nH]c1=O
Show InChI InChI=1S/C21H22F2N4O2/c22-15-3-1-14(2-4-15)20(28)24-9-12-26-10-7-17(8-11-26)27-19-6-5-16(23)13-18(19)25-21(27)29/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 12n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50257591
PNG
(CHEMBL493736 | racemic trans-N-((S)-1-(4-(6-fluoro...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C25H29FN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-13-18(26)7-8-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D2


(Homo sapiens (Human))		BDBM50258181
PNG
(3,4-difluoro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1...)
Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CCNC(=O)c4ccc(F)c(F)c4)CC3)c2c1
Show InChI InChI=1S/C21H21F3N4O2/c22-14-2-4-18-19(12-14)28(21(30)26-18)15-5-8-27(9-6-15)10-7-25-20(29)13-1-3-16(23)17(24)11-13/h1-4,11-12,15H,5-10H2,(H,25,29)(H,26,30)
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n/an/a 14n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of GFP-labelled human PLD2 HEK293 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM123744
PNG
(5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imi...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C23H24FN5O2/c24-16-5-6-18-15(13-16)14-20(26-18)22(30)25-9-12-28-10-7-17(8-11-28)29-21-4-2-1-3-19(21)27-23(29)31/h1-6,13-14,17,26H,7-12H2,(H,25,30)(H,27,31)
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n/an/a 17n/an/an/an/an/a37



Vanderbilt University



Assay Description
PLD in vitro enzymatic assay using phospholipase D2(PLD2).

Nat Chem Biol 5: 108-17 (2009)


Article DOI: 10.1038/nchembio.140
BindingDB Entry DOI: 10.7270/Q2D50KBK
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50039491
PNG
(CHEMBL3357312)
Show SMILES CC(CNC(=O)c1ccc(F)c(F)c1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26F2N4O2/c1-16(14-26-21(30)17-7-8-19(24)20(25)13-17)28-11-9-23(10-12-28)22(31)27-15-29(23)18-5-3-2-4-6-18/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,30)(H,27,31)
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n/an/a 17n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of PLD2 (unknown origin) expressed in HEK293-gfp cells by cell-based assay

Bioorg Med Chem Lett 24: 5553-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.017
BindingDB Entry DOI: 10.7270/Q20R9R15
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50258129
PNG
(4-chloro-N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro-1H-be...)
Show SMILES Fc1ccc2n(C3CCN(CCNC(=O)c4ccc(Cl)cc4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C21H22ClFN4O2/c22-15-3-1-14(2-4-15)20(28)24-9-12-26-10-7-17(8-11-26)27-19-6-5-16(23)13-18(19)25-21(27)29/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 18n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50039462
PNG
(CHEMBL3357310)
Show SMILES CC(CNC(=O)c1cc2cc(F)ccc2[nH]1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
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n/an/a 18n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of PLD2 (unknown origin) expressed in HEK293-gfp cells by cell-based assay

Bioorg Med Chem Lett 24: 5553-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.017
BindingDB Entry DOI: 10.7270/Q20R9R15
More data for this
Ligand-Target Pair
Phospholipase D2


(Homo sapiens (Human))		BDBM87120
PNG
(CHEMBL1254577 | N-[2-[1-(3-fluorophenyl)-4-keto-1,...)
Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C26H27FN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)
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n/an/a 20n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged PLD2A in human HEK293 cells

J Med Chem 53: 6706-19 (2010)


Article DOI: 10.1021/jm100814g
BindingDB Entry DOI: 10.7270/Q2XW4K1Z
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50427802
PNG
(CHEMBL2325482)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H26F2N4O2/c1-16(27-21(30)17-5-7-18(24)8-6-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)20-4-2-3-19(25)13-20/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of PLD1 in human Calu-1 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition measured af...

J Med Chem 56: 2695-9 (2013)


Article DOI: 10.1021/jm301782e
BindingDB Entry DOI: 10.7270/Q2RJ4KT8
More data for this
Ligand-Target Pair
Phospholipase D2


(Homo sapiens (Human))		BDBM154517
PNG
(ML299 (5))
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C23H26BrFN4O2/c1-16(27-21(30)17-5-7-18(24)8-6-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)20-4-2-3-19(25)13-20/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Vanderbilt University



Assay Description
Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...

ACS Chem Biol 10: 421-32 (2015)


Article DOI: 10.1021/cb500828m
BindingDB Entry DOI: 10.7270/Q2H70DK8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Phospholipase D2


(Homo sapiens (Human))		BDBM50427800
PNG
(CHEMBL2325485)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(C)c1)NC(=O)c1ccc(Br)cc1 |r|
Show InChI InChI=1S/C24H29BrN4O2/c1-17-4-3-5-21(14-17)29-16-26-23(31)24(29)10-12-28(13-11-24)15-18(2)27-22(30)19-6-8-20(25)9-7-19/h3-9,14,18H,10-13,15-16H2,1-2H3,(H,26,31)(H,27,30)/t18-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of GFP-tagged PLD2 in human HEK293 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition ...

J Med Chem 56: 2695-9 (2013)


Article DOI: 10.1021/jm301782e
BindingDB Entry DOI: 10.7270/Q2RJ4KT8
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM87245
PNG
(CHEMBL492797 | ML272 | N-(2-(4-(2-Oxo-2,3-dihydro-...)
Show SMILES O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H26N4O2/c30-24(20-10-9-18-5-1-2-6-19(18)17-20)26-13-16-28-14-11-21(12-15-28)29-23-8-4-3-7-22(23)27-25(29)31/h1-10,17,21H,11-16H2,(H,26,30)(H,27,31)
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n/an/a 21n/an/an/an/an/an/a



Vanderbilt University



Assay Description
Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...

ACS Chem Biol 10: 421-32 (2015)


Article DOI: 10.1021/cb500828m
BindingDB Entry DOI: 10.7270/Q2H70DK8
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50039488
PNG
(CHEMBL3357315)
Show SMILES FC1CN(CCNC(=O)c2ccc(F)c(F)c2)CCC1n1c2ccccc2[nH]c1=O
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n/an/a 21n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of PLD1 (unknown origin) expressed in human Calu1 cells by cell-based assay

Bioorg Med Chem Lett 24: 5553-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.017
BindingDB Entry DOI: 10.7270/Q20R9R15
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50039461
PNG
(CHEMBL3357311)
Show SMILES CC(CNC(=O)c1cc2ccccc2[nH]1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
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n/an/a 21n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of PLD1 (unknown origin) expressed in human Calu1 cells by cell-based assay

Bioorg Med Chem Lett 24: 5553-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.017
BindingDB Entry DOI: 10.7270/Q20R9R15
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM87245
PNG
(CHEMBL492797 | ML272 | N-(2-(4-(2-Oxo-2,3-dihydro-...)
Show SMILES O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H26N4O2/c30-24(20-10-9-18-5-1-2-6-19(18)17-20)26-13-16-28-14-11-21(12-15-28)29-23-8-4-3-7-22(23)27-25(29)31/h1-10,17,21H,11-16H2,(H,26,30)(H,27,31)
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n/an/a 21n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50206160
PNG
(CHEMBL245621 | Halopemide | Halopemide, 8 | N-(2-(...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C21H22ClFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 21n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells

Bioorg Med Chem Lett 19: 1916-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.057
BindingDB Entry DOI: 10.7270/Q2VM4C5W
More data for this
Ligand-Target Pair
Phospholipase D2


(Homo sapiens (Human))		BDBM87177
PNG
(5-fluoranyl-N-[2-[1-(3-fluorophenyl)-4-oxidanylide...)
Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1
Show InChI InChI=1S/C24H25F2N5O2/c25-17-2-1-3-19(14-17)31-15-28-23(33)24(31)6-9-30(10-7-24)11-8-27-22(32)21-13-16-12-18(26)4-5-20(16)29-21/h1-5,12-14,29H,6-11,15H2,(H,27,32)(H,28,33)
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n/an/a 25n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged PLD2A in human HEK293 cells

J Med Chem 53: 6706-19 (2010)


Article DOI: 10.1021/jm100814g
BindingDB Entry DOI: 10.7270/Q2XW4K1Z
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50278141
PNG
((S)-N-(1-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C27H30N4O2/c1-20(29-25(32)23-12-11-21-7-5-6-8-22(21)17-23)18-30-15-13-27(14-16-30)26(33)28-19-31(27)24-9-3-2-4-10-24/h2-12,17,20H,13-16,18-19H2,1H3,(H,28,33)(H,29,32)/t20-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of PLD1 in human calu1 cells

J Med Chem 53: 6706-19 (2010)


Article DOI: 10.1021/jm100814g
BindingDB Entry DOI: 10.7270/Q2XW4K1Z
More data for this
Ligand-Target Pair
Phospholipase D2


(Homo sapiens (Human))		BDBM87166
PNG
(5-fluoranyl-N-[2-[1-(4-fluorophenyl)-4-oxidanylide...)
Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1
Show InChI InChI=1S/C24H25F2N5O2/c25-17-1-4-19(5-2-17)31-15-28-23(33)24(31)7-10-30(11-8-24)12-9-27-22(32)21-14-16-13-18(26)3-6-20(16)29-21/h1-6,13-14,29H,7-12,15H2,(H,27,32)(H,28,33)
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n/an/a 30n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human GST-tagged PLD2A in human HEK293 cells

J Med Chem 53: 6706-19 (2010)


Article DOI: 10.1021/jm100814g
BindingDB Entry DOI: 10.7270/Q2XW4K1Z
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM123744
PNG
(5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imi...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C23H24FN5O2/c24-16-5-6-18-15(13-16)14-20(26-18)22(30)25-9-12-28-10-7-17(8-11-28)29-21-4-2-1-3-19(21)27-23(29)31/h1-6,13-14,17,26H,7-12H2,(H,25,30)(H,27,31)
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n/an/a 33n/an/an/an/an/a37



Vanderbilt University



Assay Description
Phopholipase D1(PLD)enzymatic inhibition assay using PLD1.d311

Nat Chem Biol 5: 108-17 (2009)


Article DOI: 10.1038/nchembio.140
BindingDB Entry DOI: 10.7270/Q2D50KBK
More data for this
Ligand-Target Pair
Phospholipase D1


(Homo sapiens (Human))		BDBM50039462
PNG
(CHEMBL3357310)
Show SMILES CC(CNC(=O)c1cc2cc(F)ccc2[nH]1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
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n/an/a 35n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of PLD1 (unknown origin) expressed in human Calu1 cells by cell-based assay

Bioorg Med Chem Lett 24: 5553-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.11.017
BindingDB Entry DOI: 10.7270/Q20R9R15
More data for this
Ligand-Target Pair
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