| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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| Ligand | BDBM36495 |
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| Substrate/Competitor | BDBM22111 |
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| Meas. Tech. | Enzyme Activity Assay |
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| pH | 7.5±0 |
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| Temperature | 298.15±0 K |
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| Kd | 0.012±0.0 nM |
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| Citation |  Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol2:725-34 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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| Name: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
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| Synonyms: | 5 -methylthioadenosine nucleosidase | 5'-methylthioadenosine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) | MTA/SAH nucleosidase | MTAN | MTNN_ECOLI | Methylthioadenosine Nucleosidase(MTAN) | P46 | S-adenosylhomocysteine nucleosidase | mtn | mtnN | pfs | yadA |
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| Type: | Enzyme |
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| Mol. Mass.: | 24347.14 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | P0AF12 |
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| Residue: | 232 |
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| Sequence: | MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGAT
LLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFK
ADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAH
VCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
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| BDBM36495 |
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| BDBM22111 |
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| Name | BDBM36495 |
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| Synonyms: | CHEMBL554642 | ImmA-Bn |
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| Type | Small organic moelcule |
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| Emp. Form. | C18H21N5O2S |
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| Mol. Mass. | 371.457 |
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| SMILES | Nc1ncnc2c(c[nH]c12)C1NC(CSCc2ccccc2)C(O)C1O |
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| Structure | 
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