| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosylhomocysteine nucleosidase |
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| Ligand | BDBM36435 |
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| Substrate/Competitor | BDBM22111 |
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| Meas. Tech. | Enzyme Activity Assay |
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| pH | 7.5±0 |
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| Temperature | 298.15±0 K |
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| Kd | 10±0.0 nM |
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| Citation |  Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol2:725-34 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Adenosylhomocysteine nucleosidase |
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| Name: | Adenosylhomocysteine nucleosidase |
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| Synonyms: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | Methylthioadenosine Nucleosidase (MTAN) | mtnN |
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| Type: | Enzyme |
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| Mol. Mass.: | 24666.14 |
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| Organism: | Streptococcus pneumoniae |
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| Description: | J0VBT9 |
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| Residue: | 230 |
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| Sequence: | MKIGIIAAMPEELAYLVQHLDNTQEQVVLGNTYHTGTIASHEVVLVESGIGKVMSAMSVA
ILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDVDVTAFGYAYGQMAQQPLYFE
SDKTFVAQIQESLSQLDQNWHLGLIATGDSFVAGNDKIEAIKSHFPEVLAVEMEGAAIAQ
AAHALNLPVLVIRAMSDNANHEANIFFDEFIIEAGRRSAQVLLTFLKALD
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| BDBM36435 |
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| BDBM22111 |
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| Name | BDBM36435 |
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| Synonyms: | (3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthio-methyl-3-hydroxypyrrolidine, 8 | CID11404039 | DADMe-ImmA-Et |
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| Type | Small organic molecule |
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| Emp. Form. | C14H21N5OS |
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| Mol. Mass. | 307.414 |
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| SMILES | CCSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O |
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| Structure | 
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