| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosylhomocysteine nucleosidase |
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| Ligand | BDBM36497 |
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| Substrate/Competitor | BDBM22111 |
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| Meas. Tech. | Enzyme Activity Assay |
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| pH | 7.5±0 |
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| Temperature | 298.15±0 K |
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| Kd | 2.4±0.0 nM |
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| Citation |  Gutierrez, JA; Luo, M; Singh, V; Li, L; Brown, RL; Norris, GE; Evans, GB; Furneaux, RH; Tyler, PC; Painter, GF; Lenz, DH; Schramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol2:725-34 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Adenosylhomocysteine nucleosidase |
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| Name: | Adenosylhomocysteine nucleosidase |
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| Synonyms: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | Methylthioadenosine Nucleosidase (MTAN) | mtnN |
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| Type: | Enzyme |
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| Mol. Mass.: | 24666.14 |
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| Organism: | Streptococcus pneumoniae |
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| Description: | J0VBT9 |
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| Residue: | 230 |
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| Sequence: | MKIGIIAAMPEELAYLVQHLDNTQEQVVLGNTYHTGTIASHEVVLVESGIGKVMSAMSVA
ILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDVDVTAFGYAYGQMAQQPLYFE
SDKTFVAQIQESLSQLDQNWHLGLIATGDSFVAGNDKIEAIKSHFPEVLAVEMEGAAIAQ
AAHALNLPVLVIRAMSDNANHEANIFFDEFIIEAGRRSAQVLLTFLKALD
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| BDBM36497 |
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| BDBM22111 |
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| Name | BDBM36497 |
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| Synonyms: | CHEMBL191436 | DADMe-ImmA-Bn |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N5OS |
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| Mol. Mass. | 369.484 |
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| SMILES | Nc1ncnc2c(CN3CC(O)C(CSCc4ccccc4)C3)c[nH]c12 |
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| Structure | 
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