| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin D |
|---|
| Ligand | BDBM36565 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | High Through-Put Fluorescence Assay |
|---|
| pH | 3.7±0 |
|---|
| Ki | 356±31 nM |
|---|
| Citation |  Kick, EK; Roe, DC; Skillman, AG; Liu, G; Ewing, TJ; Sun, Y; Kuntz, ID; Ellman, JA Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D. Chem Biol4:297-307 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Cathepsin D |
|---|
| Name: | Cathepsin D |
|---|
| Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 44551.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
|---|
| Residue: | 412 |
|---|
| Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
|
|
|
|---|
| BDBM36565 |
|---|
| n/a |
|---|
| Name | BDBM36565 |
|---|
| Synonyms: | FBB |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H38N4O5S2 |
|---|
| Mol. Mass. | 598.777 |
|---|
| SMILES | COc1cccc(CCN(CC(O)[C@@H](NC(=O)Cn2c(O)csc2=S)c2ccccc2)C(=O)NC2CCCCC2)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
