| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Methionine aminopeptidase 2 |
|---|
| Ligand | BDBM36599 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Assay |
|---|
| pH | 7.35±0 |
|---|
| Temperature | 310.15±0 K |
|---|
| IC50 | 45±12 nM |
|---|
| Citation |  Griffith, EC; Su, Z; Turk, BE; Chen, S; Chang, YH; Wu, Z; Biemann, K; Liu, JO Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chem Biol4:461-71 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Methionine aminopeptidase 2 |
|---|
| Name: | Methionine aminopeptidase 2 |
|---|
| Synonyms: | Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52884.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P50579 |
|---|
| Residue: | 478 |
|---|
| Sequence: | MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
|
|
|
|---|
| BDBM36599 |
|---|
| n/a |
|---|
| Name | BDBM36599 |
|---|
| Synonyms: | FOS-201 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H28O5S |
|---|
| Mol. Mass. | 332.456 |
|---|
| SMILES | [#6]-[#8]-[#6@@H]1-[#6@H](-[#8])-[#6]-[#6][C@]([#8])([#16]-[#6])[C@@]1([#8])[C@]1([#6])[#8]-[#6]1-[#6]\[#6]=[#6](\[#6])-[#6] |r| |
|---|
| Structure | 
|
|---|
Search and Browse
