Reaction Details |
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Target | cAMP-dependent protein kinase |
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Ligand | BDBM3207 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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pH | 7.5±0 |
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Temperature | 303.15±0 K |
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Ki | 3.9±0 nM |
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IC50 | 6.3±0.0 nM |
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Citation | Koide, K; Bunnage, ME; Gomez Paloma, L; Kanter, JR; Taylor, SS; Brunton, LL; Nicolaou, KC Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chem Biol2:601-8 (1995) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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cAMP-dependent protein kinase |
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Name: | cAMP-dependent protein kinase |
Synonyms: | Cyclic AMP-dependent protein kinase (PKA) | PKA catalytic subunit alpha | Serine/threonine-protein kinase | cAMP-dependent protein kinase alpha-catalytic subunit |
Type: | Enzyme |
Mol. Mass.: | 40766.33 |
Organism: | Oryctolagus cuniculus (Rabbit) |
Description: | Q95J97 |
Residue: | 351 |
Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAQLDQFERIKTLGTGSFGRVML
SKHKETGNHYAMKILDKQKVVKLKQIEHTLNVKRILQAVNFPFLVKLEFSFKENSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQQTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAADYPPFF
ADQPIQIYEKIVYGKVRFPSHFSSDLKDLLRNLQQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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BDBM3207 |
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n/a |
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Name | BDBM3207 |
Synonyms: | 10''-Deoxybalanol, 4 | 2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl]oxy}carbonyl)phenyl]carbonyl}benzoic acid | 4-trans-[4-(2-Carboxybenzoyl)-3,5-dihydroxybenzoyloxy]-3-(4-hydroxybenzamido)azepane | CHEMBL193697 | Modified Benzophenone Ring, Balanol Analog 7 |
Type | Small organic molecule |
Emp. Form. | C28H26N2O9 |
Mol. Mass. | 534.514 |
SMILES | OC(=O)c1ccccc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r| |
Structure |
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