| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C beta type |
|---|
| Ligand | BDBM3207 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 7.5±0 |
|---|
| Temperature | 303.15±0 K |
|---|
| Ki | 640±0 nM |
|---|
| IC50 | 834±0.0 nM |
|---|
| Citation |  Koide, K; Bunnage, ME; Gomez Paloma, L; Kanter, JR; Taylor, SS; Brunton, LL; Nicolaou, KC Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chem Biol2:601-8 (1995) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Protein kinase C beta type |
|---|
| Name: | Protein kinase C beta type |
|---|
| Synonyms: | KPCB_RAT | PKC, rat brain | Pkcb | Prkcb | Prkcb1 | Protein Kinase C | Protein kinase C (PKC) | Protein kinase C beta |
|---|
| Type: | Enzyme Mixture |
|---|
| Mol. Mass.: | 76755.54 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | PKC from rat brain is known to contain predominately the conventional PKC isoforms, alpha, beta I, beta II, gamma. |
|---|
| Residue: | 671 |
|---|
| Sequence: | MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEE
LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV
|
|
|
|---|
| BDBM3207 |
|---|
| n/a |
|---|
| Name | BDBM3207 |
|---|
| Synonyms: | 10''-Deoxybalanol, 4 | 2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl]oxy}carbonyl)phenyl]carbonyl}benzoic acid | 4-trans-[4-(2-Carboxybenzoyl)-3,5-dihydroxybenzoyloxy]-3-(4-hydroxybenzamido)azepane | CHEMBL193697 | Modified Benzophenone Ring, Balanol Analog 7 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H26N2O9 |
|---|
| Mol. Mass. | 534.514 |
|---|
| SMILES | OC(=O)c1ccccc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
