Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM264112 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Rat Synaptosome Binding Assay |
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pH | 7.4±n/a |
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IC50 | 1.40±n/a nM |
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Comments | extracted |
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Citation | Zhang, Y; Jin, C; Zhou, R Substituted piperazine compounds and methods of use thereof US Patent US9714232 Publication Date 7/25/2017 |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM264112 |
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n/a |
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Name | BDBM264112 |
Synonyms: | 3-(4-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phenyl)piperazin-1-yl)butyl)-1H-indole-5-carbonitrile | US9714232, 25 |
Type | Small organic molecule |
Emp. Form. | C28H27F2N5O |
Mol. Mass. | 487.5437 |
SMILES | Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1 |
Structure |
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