Reaction Details |
| Report a problem with these data |
Target | Thyroid peroxidase |
---|
Ligand | BDBM312258 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Pharmacological Activity Assay |
---|
IC50 | 46000±n/a nM |
---|
Citation | Inghardt, TB; Johannesson, P; Jurva, U; Michaelsson, E; Lindstedt-Alstermark, E; Tomkinson, N; Stonehouse, JP; Gan, L 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase US Patent US10016430 Publication Date 7/10/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Thyroid peroxidase |
---|
Name: | Thyroid peroxidase |
Synonyms: | PERT_HUMAN | TPO | Thyroid peroxidase | Thyroid peroxidase (TPO) |
Type: | Enzyme |
Mol. Mass.: | 102965.07 |
Organism: | Homo sapiens (Human) |
Description: | P07202 |
Residue: | 933 |
Sequence: | MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
|
|
|
BDBM312258 |
---|
n/a |
---|
Name | BDBM312258 |
Synonyms: | 1-(2-{[(2-Methylpropyl)amino]methyl}benzyl)-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | US10016430, Example 12 | US11000525, Example 12 | US9616063, 12 |
Type | Small organic molecule |
Emp. Form. | C18H22N4OS |
Mol. Mass. | 342.458 |
SMILES | CC(C)CNCc1ccccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S |$;;;;HN;;;;;;;;;;;;;HN;;;;;;$| |
Structure |
|