| Reaction Details |
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 | Report a problem with these data |
| Target | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
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| Ligand | BDBM267070 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PFKFB4 Assay |
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| IC50 | 1800±n/a nM |
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| Citation |  Martinsson, J; Faernegardh, K; Joensson, M; Ringom, R Bisarylsulfonamides useful in the treatment of inflammation and cancer US Patent US9718809 Publication Date 8/1/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
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| Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
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| Synonyms: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) | F264_HUMAN | PFKFB4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 54039.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16877 |
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| Residue: | 469 |
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| Sequence: | MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLT
RYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSE
EGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYV
NRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVY
YLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVW
TSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRY
PKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTV
LKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ
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| BDBM267070 |
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| n/a |
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| Name | BDBM267070 |
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| Synonyms: | 1-Benzylpyrrolidin-3-yl 2-hydroxy-4-{[(2,4,5-trichloro-3-thienyl)sulfonyl]amino}benzoate | US9718809, 204 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19Cl3N2O5S2 |
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| Mol. Mass. | 561.886 |
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| SMILES | Oc1cc(NS(=O)(=O)c2c(Cl)sc(Cl)c2Cl)ccc1C(=O)OC1CCN(Cc2ccccc2)C1 |
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| Structure | 
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