Ki Summary

Reaction Details

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Target

Guanyl-specific ribonuclease T1

Ligand

BDBM44482

Substrate/Competitor

n/a

Meas. Tech.

Counterscreen for inhibitors of tRNA 2'-phosphotransferase (TPT1): fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of RNAse T1.

IC50

9846±n/a nM

Citation

PubChem, PC Counterscreen for inhibitors of tRNA 2'-phosphotransferase (TPT1): fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of RNAse T1. PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Guanyl-specific ribonuclease T1

Name:

Guanyl-specific ribonuclease T1

Synonyms:

RNT1_ASPOR | rntA | unnamed protein product

Type:

Enzyme Catalytic Domain

Mol. Mass.:

13952.57

Organism:

Aspergillus oryzae

Description:

gi_83774548

Residue:

130

Sequence:

MMYSKLLTLTTLLLPTALALPSLVERACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVG
SNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTG
ASGNNFVECT

BDBM44482

n/a

Name

BDBM44482

Synonyms:

2-[(5Z)-5-[(E)-3-(2-furanyl)prop-2-enylidene]-4-oxo-2-sulfanylidene-3-thiazolidinyl]-3-methylbutanoic acid | 2-[(5Z)-5-[(E)-3-(2-furyl)prop-2-enylidene]-4-keto-2-thioxo-thiazolidin-3-yl]-3-methyl-butyric acid | 2-[(5Z)-5-[(E)-3-(furan-2-yl)prop-2-enylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-methyl-butanoic acid | 2-[(5Z)-5-[(E)-3-(furan-2-yl)prop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-methylbutanoic acid | 2-{5-[(E)-3-Furan-2-yl-prop-2-en-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-3-methyl-butyric acid | MLS000551672 | SMR000145597 | cid_6393068

Type

Small organic molecule

Emp. Form.

C15H15NO4S2

Mol. Mass.

337.414

SMILES

CC(C)C(N1C(=S)S\C(=C/C=C/c2ccco2)C1=O)C(O)=O

Structure