| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM2487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HIV-1 RT Assay |
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| IC50 | 40±n/a nM |
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| Citation |  Ragno, R; Mai, A; Sbardella, G; Artico, M; Massa, S; Musiu, C; Mura, M; Marturana, F; Cadeddu, A; La Colla, P Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181C variant. J Med Chem47:928-34 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM2487 |
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| n/a |
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| Name | BDBM2487 |
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| Synonyms: | 2-(cyclopentylamino)-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydropyrimidin-4-one | 2-Cyclopentylamino-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydropyrimidin-4(3H)-one | F2-NH-DABO 9c |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19F2N3O |
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| Mol. Mass. | 319.3491 |
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| SMILES | CC(c1cc(=O)[nH]c(NC2CCCC2)n1)c1c(F)cccc1F |
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| Structure | 
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