| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Estrogen receptor |
|---|
| Ligand | BDBM269447 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ER Transcription Assay (MCF7 Cells) |
|---|
| pH | 5.1±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 1.20±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Burks, HE; Dechantsreiter, MA; He, G; Nunez, J; Peukert, S; Springer, C; Sun, Y; Thomsen, NM; Tria, GS; Yu, B Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders US Patent US10058534 Publication Date 8/28/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Estrogen receptor |
|---|
| Name: | Estrogen receptor |
|---|
| Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 66230.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03372 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
|
|
|
|---|
| BDBM269447 |
|---|
| n/a |
|---|
| Name | BDBM269447 |
|---|
| Synonyms: | (E)-2-(2- isopropylphenyl)-3-(4- (2-(5-methyl-1,3,4- oxadiazol-2- yl)vinyl)phenoxy)benzo [b]thiophen-6-ol | US10058534, 102 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H24N2O3S |
|---|
| Mol. Mass. | 468.567 |
|---|
| SMILES | CC(C)c1ccccc1-c1sc2cc(O)ccc2c1Oc1ccc(\C=C\c2nnc(C)o2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
