| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1) |
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| Ligand | BDBM76009 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Counterscreen for NR2E3 inverse agonists |
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| IC50 | 941±n/a nM |
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| Citation |  PubChem, PC Counterscreen for NR2E3 inverse agonists: TR-FRET-based biochemical high throughput dose response assay to identify inverse agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1) |
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| Name: | Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1) |
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| Synonyms: | CTG26 | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2 (TRAC-1) | nuclear receptor corepressor 2 isoform 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 81401.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y618-2 gi_116256445 |
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| Residue: | 766 |
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| Sequence: | MAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLP
TAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVE
HAPIWRPGTEQSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKG
IITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRV
ARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPH
HASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLT
HDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPG
VKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYL
PPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLL
YRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYN
ISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKALMGGGGKAKVSGRPSS
RKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRL
QAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE
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| BDBM76009 |
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| n/a |
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| Name | BDBM76009 |
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| Synonyms: | 3-(3,4-dimethoxyphenyl)-N-[2-[(4-fluorobenzyl)amino]-2-keto-ethyl]-4-keto-phthalazine-1-carboxamide | 3-(3,4-dimethoxyphenyl)-N-[2-[(4-fluorophenyl)methylamino]-2-oxidanylidene-ethyl]-4-oxidanylidene-phthalazine-1-carboxamide | 3-(3,4-dimethoxyphenyl)-N-[2-[(4-fluorophenyl)methylamino]-2-oxoethyl]-4-oxo-1-phthalazinecarboxamide | 3-(3,4-dimethoxyphenyl)-N-[2-[(4-fluorophenyl)methylamino]-2-oxoethyl]-4-oxophthalazine-1-carboxamide | MLS000936274 | SMR000620955 | cid_22334119 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23FN4O5 |
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| Mol. Mass. | 490.483 |
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| SMILES | COc1ccc(cc1OC)-n1nc(C(=O)NCC(=O)NCc2ccc(F)cc2)c2ccccc2c1=O |
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| Structure | 
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