| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM18069 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Temperature | 298.15±0 K |
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| IC50 | 7300±1800 nM |
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| Citation |  Liu, J; Bolstad, DB; Smith, AE; Priestley, ND; Wright, DL; Anderson, AC Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase. Chem Biol15:990-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate Reductase (DHFR) |
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| Type: | Protein |
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| Mol. Mass.: | 25053.64 |
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| Organism: | Candida Glabrata |
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| Description: | Q6FPH0 |
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| Residue: | 217 |
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| Sequence: | MSKVPVVGIVAALLPEMGIGFQGNLPWRLAKEMKYFREVTTLTNDNSKQNVVIMGRKTWE
SIPQKFRPLPKRINVVVSRSFDGELRKVEDGIYHSNSLRNCLTALQSSLANENKIERIYI
IGGGEIYRQSMDLADHWLITKIMPLPETTIPQMDTFLQKQELEQRFYDNSDKLVDFLPSS
IQLEGRLTSQEWNGELVKGLPVQEKGYQFYFTLYTKK
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| BDBM18069 |
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| n/a |
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| Name | BDBM18069 |
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| Synonyms: | 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine | CHEMBL22 | TMP | Trimethoprim | Trimethoprim (TMP) | US10870625, Compound TMP |
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| Type | Small organic molecule |
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| Emp. Form. | C14H18N4O3 |
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| Mol. Mass. | 290.3177 |
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| SMILES | COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC |
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| Structure | 
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