Reaction Details |
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Target | HIV-1 protease |
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Ligand | BDBM81676 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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Ki | 540±0.0 nM |
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Citation | Chellappan, S; Kiran Kumar Reddy, GS; Ali, A; Nalam, MN; Anjum, SG; Cao, H; Kairys, V; Fernandes, MX; Altman, MD; Tidor, B; Rana, TM; Schiffer, CA; Gilson, MK Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis. Chem Biol Drug Des69:298-313 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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HIV-1 protease |
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Name: | HIV-1 protease |
Synonyms: | n/a |
Type: | Protein |
Mol. Mass.: | 10653.94 |
Organism: | Human immunodeficiency virus |
Description: | O90783 |
Residue: | 98 |
Sequence: | PQVTLWQRPLVTIRVGGQLKEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD
QITVEICGHKAIGTVLVGPTPVNIIGRNLLTIGCTLNF
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BDBM81676 |
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n/a |
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Name | BDBM81676 |
Synonyms: | CARB-KB49 |
Type | Small organic molecule |
Emp. Form. | C22H31N3O7S |
Mol. Mass. | 481.562 |
SMILES | CNC(=O)CCC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN(C[C@@H](C)O)S(=O)(=O)c1ccco1 |r| |
Structure |
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