| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM106152 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Acetyl-Histone Binding Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | >10000±0.0 nM |
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| Comments | extracted |
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| Citation |  Bradner, JE; Gray, NS; Qi, J; McKeown, MR; Buckley, D Diazepane derivatives and uses thereof US Patent US9695172 Publication Date 7/4/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM106152 |
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| n/a |
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| Name | BDBM106152 |
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| Synonyms: | US9695172, 2-221 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N5O3S |
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| Mol. Mass. | 409.462 |
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| SMILES | CN1c2ccccc2C(=O)N(C)c2ccc(Nc3ccc(cc3)S(N)(=O)=O)nc12 |
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| Structure | 
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