| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Leucyl-cystinyl aminopeptidase |
|---|
| Ligand | BDBM271218 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition of Human P-LAP (hP-LAP) Assay |
|---|
| IC50 | 1.50±n/a nM |
|---|
| Citation |  Kawaguchi, K; Ishihata, A; Inagaki, Y; Tsuchiya, K; Hanadate, T; Kanai, A; Kaizawa, H; Kazami, J; Morikawa, H; Hiramoto, M; Enjo, K; Takamatsu, H Pyridine derivative US Patent US10059720 Publication Date 8/28/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Leucyl-cystinyl aminopeptidase |
|---|
| Name: | Leucyl-cystinyl aminopeptidase |
|---|
| Synonyms: | Aminopeptidase | Aminopeptidase (P-LAP) | Cystinyl aminopeptidase | IRAP | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | LCAP_HUMAN | LNPEP | Leucyl-cystinyl aminopeptidase, pregnancy serum form | OTASE | Oxytocinase | P-LAP | Placental leucine aminopeptidase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 117334.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1473494 |
|---|
| Residue: | 1025 |
|---|
| Sequence: | MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV
AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS
LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH
GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR
SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW
NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT
LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT
EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP
YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE
KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM
KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS
EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS
YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS
LTWWL
|
|
|
|---|
| BDBM271218 |
|---|
| n/a |
|---|
| Name | BDBM271218 |
|---|
| Synonyms: | US10059720, Example 33 | US10975091, Example 33 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H34N4O3 |
|---|
| Mol. Mass. | 402.5304 |
|---|
| SMILES | CC(C)C[C@H](N)[C@](O)(Cc1cc2n(CCC3CCCCC3)cnc2cn1)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
