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Compile Data Set for Download or QSAR

Found 760 hits with Last Name = 'kaizawa' and Initial = 'h'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM25041
PNG
(N'-[(1E)-{6-cyanoimidazo[1,2-a]pyridin-3-yl}methyl...)
Show SMILES CN(\N=C\c1cnc2ccc(cn12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O
Show InChI InChI=1S/C17H14N6O4S/c1-12-3-5-14(23(24)25)7-16(12)28(26,27)21(2)20-10-15-9-19-17-6-4-13(8-18)11-22(15)17/h3-7,9-11H,1-2H3/b20-10+
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n/an/a 0.260n/an/an/an/a7.422



Astellas Pharma Inc.



Assay Description
The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...


Bioorg Med Chem 15: 5837-44 (2007)


Article DOI: 10.1016/j.bmc.2007.05.070
BindingDB Entry DOI: 10.7270/Q2X928M7
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM25036
PNG
(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Show SMILES CN(\N=C\c1cnc2ccc(Br)cn12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O
Show InChI InChI=1S/C16H14BrN5O4S/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16/h3-10H,1-2H3/b19-9+
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n/an/a 0.300n/an/an/an/a7.422



Astellas Pharma Inc.



Assay Description
The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...


Bioorg Med Chem 15: 5837-44 (2007)


Article DOI: 10.1016/j.bmc.2007.05.070
BindingDB Entry DOI: 10.7270/Q2X928M7
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130711
PNG
(US8822448, 23)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)NCC1(CCCCC1)N1CCOCC1
Show InChI InChI=1S/C28H37N5O4/c1-19-15-24-22(25-23(27(35)31-24)17-30-33(25)20-5-11-36-12-6-20)16-21(19)26(34)29-18-28(7-3-2-4-8-28)32-9-13-37-14-10-32/h15-17,20H,2-14,18H2,1H3,(H,29,34)(H,31,35)
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n/an/a 0.400n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271230
PNG
(US10059720, Example 45 | US10975091, Example 45)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C28H32N2O6S/c1-37(34,35)25-13-11-20(12-14-25)19-7-9-21(10-8-19)26(29)28(33,27(31)32)18-22-17-24(15-16-30-22)36-23-5-3-2-4-6-23/h7-17,23,26,33H,2-6,18,29H2,1H3,(H,31,32)/t26-,28+/m0/s1
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n/an/a 0.420n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271230
PNG
(US10059720, Example 45 | US10975091, Example 45)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C28H32N2O6S/c1-37(34,35)25-13-11-20(12-14-25)19-7-9-21(10-8-19)26(29)28(33,27(31)32)18-22-17-24(15-16-30-22)36-23-5-3-2-4-6-23/h7-17,23,26,33H,2-6,18,29H2,1H3,(H,31,32)/t26-,28+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271290
PNG
(US10059720, Example 105 | US10975091, Example 105)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-8,-3.08,;-6.67,-2.31,;-5.33,-3.08,;-4,-2.31,;-2.67,-3.08,;-2.67,-4.62,;-1.33,-2.31,;-.56,-.98,;,-3.08,;1.33,-2.31,;1.33,-.77,;2.67,,;2.67,1.54,;4,2.31,;5.33,1.54,;6.67,2.31,;6.67,3.85,;8,4.62,;5.33,4.62,;4,3.85,;4,-.77,;4,-2.31,;2.67,-3.08,;-2.1,-.98,;-3.59,-1.37,;-1.33,.36,)|
Show InChI InChI=1S/C19H30N2O4S/c1-3-26-12-17(20)19(24,18(22)23)11-14-10-16(8-9-21-14)25-15-6-4-13(2)5-7-15/h8-10,13,15,17,24H,3-7,11-12,20H2,1-2H3,(H,22,23)/t13-,15-,17-,19+/m0/s1
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n/an/a 0.620n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271290
PNG
(US10059720, Example 105 | US10975091, Example 105)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-8,-3.08,;-6.67,-2.31,;-5.33,-3.08,;-4,-2.31,;-2.67,-3.08,;-2.67,-4.62,;-1.33,-2.31,;-.56,-.98,;,-3.08,;1.33,-2.31,;1.33,-.77,;2.67,,;2.67,1.54,;4,2.31,;5.33,1.54,;6.67,2.31,;6.67,3.85,;8,4.62,;5.33,4.62,;4,3.85,;4,-.77,;4,-2.31,;2.67,-3.08,;-2.1,-.98,;-3.59,-1.37,;-1.33,.36,)|
Show InChI InChI=1S/C19H30N2O4S/c1-3-26-12-17(20)19(24,18(22)23)11-14-10-16(8-9-21-14)25-15-6-4-13(2)5-7-15/h8-10,13,15,17,24H,3-7,11-12,20H2,1-2H3,(H,22,23)/t13-,15-,17-,19+/m0/s1
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n/an/a 0.620n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271330
PNG
(US10059720, Example 145 | US10975091, Example 145)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:7.8,5.5,17.17,wD:7.7,14.13,(-8.67,-2.31,;-7.34,-3.08,;-6,-2.31,;-4.67,-3.08,;-3.33,-2.31,;-2,-3.08,;-2,-4.62,;-.67,-2.31,;.1,-.98,;.67,-3.08,;2,-2.31,;2,-.77,;3.33,,;3.33,1.54,;4.67,2.31,;6,1.54,;7.34,2.31,;7.34,3.85,;8.67,4.62,;6,4.62,;4.67,3.85,;4.67,-.77,;4.67,-2.31,;3.33,-3.08,;-1.44,-.98,;-2.92,-1.37,;-.67,.36,)|
Show InChI InChI=1S/C20H32N2O4S/c1-3-10-27-13-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(2)5-7-16/h8-9,11,14,16,18,25H,3-7,10,12-13,21H2,1-2H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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n/an/a 0.770n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM25037
PNG
(N'-[(1E)-{6-chloroimidazo[1,2-a]pyridin-3-yl}methy...)
Show SMILES CN(\N=C\c1cnc2ccc(Cl)cn12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O
Show InChI InChI=1S/C16H14ClN5O4S/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16/h3-10H,1-2H3/b19-9+
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n/an/a 0.770n/an/an/an/a7.422



Astellas Pharma Inc.



Assay Description
The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...


Bioorg Med Chem 15: 5837-44 (2007)


Article DOI: 10.1016/j.bmc.2007.05.070
BindingDB Entry DOI: 10.7270/Q2X928M7
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271330
PNG
(US10059720, Example 145 | US10975091, Example 145)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:7.8,5.5,17.17,wD:7.7,14.13,(-8.67,-2.31,;-7.34,-3.08,;-6,-2.31,;-4.67,-3.08,;-3.33,-2.31,;-2,-3.08,;-2,-4.62,;-.67,-2.31,;.1,-.98,;.67,-3.08,;2,-2.31,;2,-.77,;3.33,,;3.33,1.54,;4.67,2.31,;6,1.54,;7.34,2.31,;7.34,3.85,;8.67,4.62,;6,4.62,;4.67,3.85,;4.67,-.77,;4.67,-2.31,;3.33,-3.08,;-1.44,-.98,;-2.92,-1.37,;-.67,.36,)|
Show InChI InChI=1S/C20H32N2O4S/c1-3-10-27-13-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(2)5-7-16/h8-9,11,14,16,18,25H,3-7,10,12-13,21H2,1-2H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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n/an/a 0.770n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271257
PNG
(US10059720, Example 72 | US10975091, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC(C)(C)C)c(C)cn1)C(O)=O |r|
Show InChI InChI=1S/C20H34N2O4/c1-13(2)9-17(21)20(25,18(23)24)11-15-10-16(14(3)12-22-15)26-8-7-19(4,5)6/h10,12-13,17,25H,7-9,11,21H2,1-6H3,(H,23,24)/t17-,20+/m0/s1
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n/an/a 0.770n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271257
PNG
(US10059720, Example 72 | US10975091, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC(C)(C)C)c(C)cn1)C(O)=O |r|
Show InChI InChI=1S/C20H34N2O4/c1-13(2)9-17(21)20(25,18(23)24)11-15-10-16(14(3)12-22-15)26-8-7-19(4,5)6/h10,12-13,17,25H,7-9,11,21H2,1-6H3,(H,23,24)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271230
PNG
(US10059720, Example 45 | US10975091, Example 45)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C28H32N2O6S/c1-37(34,35)25-13-11-20(12-14-25)19-7-9-21(10-8-19)26(29)28(33,27(31)32)18-22-17-24(15-16-30-22)36-23-5-3-2-4-6-23/h7-17,23,26,33H,2-6,18,29H2,1H3,(H,31,32)/t26-,28+/m0/s1
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n/an/a 0.890n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
hP-LAP: HEK293 cells forced to transiently express hP-LAP were prepared by lipofection, homogenized, and then subjected to ultracentrifugation at 100...


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271230
PNG
(US10059720, Example 45 | US10975091, Example 45)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C28H32N2O6S/c1-37(34,35)25-13-11-20(12-14-25)19-7-9-21(10-8-19)26(29)28(33,27(31)32)18-22-17-24(15-16-30-22)36-23-5-3-2-4-6-23/h7-17,23,26,33H,2-6,18,29H2,1H3,(H,31,32)/t26-,28+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271310
PNG
(US10059720, Example 125 | US10975091, Example 125)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)F)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(7.34,4.62,;6,3.85,;6,2.31,;4.67,1.54,;3.33,2.31,;3.33,3.85,;4.67,4.62,;2,1.54,;2,,;3.33,-.77,;3.33,-2.31,;2,-3.08,;.67,-2.31,;-.67,-3.08,;-2,-2.31,;-1.23,-.98,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-2.31,;-6,-3.08,;-7.34,-2.31,;-6,-4.62,;-7.34,-3.85,;-2.77,-.98,;-2,.36,;-4.26,-1.37,;.67,-.77,)|
Show InChI InChI=1S/C20H31FN2O4/c1-13-4-6-15(7-5-13)27-16-8-9-23-14(10-16)11-20(26,18(24)25)17(22)12-19(2,3)21/h8-10,13,15,17,26H,4-7,11-12,22H2,1-3H3,(H,24,25)/t13-,15-,17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271310
PNG
(US10059720, Example 125 | US10975091, Example 125)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)F)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(7.34,4.62,;6,3.85,;6,2.31,;4.67,1.54,;3.33,2.31,;3.33,3.85,;4.67,4.62,;2,1.54,;2,,;3.33,-.77,;3.33,-2.31,;2,-3.08,;.67,-2.31,;-.67,-3.08,;-2,-2.31,;-1.23,-.98,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-2.31,;-6,-3.08,;-7.34,-2.31,;-6,-4.62,;-7.34,-3.85,;-2.77,-.98,;-2,.36,;-4.26,-1.37,;.67,-.77,)|
Show InChI InChI=1S/C20H31FN2O4/c1-13-4-6-15(7-5-13)27-16-8-9-23-14(10-16)11-20(26,18(24)25)17(22)12-19(2,3)21/h8-10,13,15,17,26H,4-7,11-12,22H2,1-3H3,(H,24,25)/t13-,15-,17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271316
PNG
(US10059720, Example 131 | US10975091, Example 131)
Show SMILES CC(C)CC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O |r|
Show InChI InChI=1S/C21H30N2O4/c1-13(2)3-8-19(22)21(26,20(24)25)12-17-16-11-15(7-6-14-4-5-14)27-18(16)9-10-23-17/h9-11,13-14,19,26H,3-8,12,22H2,1-2H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271316
PNG
(US10059720, Example 131 | US10975091, Example 131)
Show SMILES CC(C)CC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O |r|
Show InChI InChI=1S/C21H30N2O4/c1-13(2)3-8-19(22)21(26,20(24)25)12-17-16-11-15(7-6-14-4-5-14)27-18(16)9-10-23-17/h9-11,13-14,19,26H,3-8,12,22H2,1-2H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271309
PNG
(US10059720, Example 124 | US10975091, Example 124)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)C)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(7.34,4.62,;6,3.85,;6,2.31,;4.67,1.54,;3.33,2.31,;3.33,3.85,;4.67,4.62,;2,1.54,;2,,;3.33,-.77,;3.33,-2.31,;2,-3.08,;.67,-2.31,;-.67,-3.08,;-2,-2.31,;-1.23,-.98,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-2.31,;-6,-3.08,;-7.34,-3.85,;-6.77,-1.75,;-5.23,-4.41,;-2.77,-.98,;-2,.36,;-4.26,-1.37,;.67,-.77,)|
Show InChI InChI=1S/C21H34N2O4/c1-14-5-7-16(8-6-14)27-17-9-10-23-15(11-17)12-21(26,19(24)25)18(22)13-20(2,3)4/h9-11,14,16,18,26H,5-8,12-13,22H2,1-4H3,(H,24,25)/t14-,16-,18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271309
PNG
(US10059720, Example 124 | US10975091, Example 124)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)C)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(7.34,4.62,;6,3.85,;6,2.31,;4.67,1.54,;3.33,2.31,;3.33,3.85,;4.67,4.62,;2,1.54,;2,,;3.33,-.77,;3.33,-2.31,;2,-3.08,;.67,-2.31,;-.67,-3.08,;-2,-2.31,;-1.23,-.98,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-2.31,;-6,-3.08,;-7.34,-3.85,;-6.77,-1.75,;-5.23,-4.41,;-2.77,-.98,;-2,.36,;-4.26,-1.37,;.67,-.77,)|
Show InChI InChI=1S/C21H34N2O4/c1-14-5-7-16(8-6-14)27-17-9-10-23-15(11-17)12-21(26,19(24)25)18(22)13-20(2,3)4/h9-11,14,16,18,26H,5-8,12-13,22H2,1-4H3,(H,24,25)/t14-,16-,18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271257
PNG
(US10059720, Example 72 | US10975091, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC(C)(C)C)c(C)cn1)C(O)=O |r|
Show InChI InChI=1S/C20H34N2O4/c1-13(2)9-17(21)20(25,18(23)24)11-15-10-16(14(3)12-22-15)26-8-7-19(4,5)6/h10,12-13,17,25H,7-9,11,21H2,1-6H3,(H,23,24)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
hP-LAP: HEK293 cells forced to transiently express hP-LAP were prepared by lipofection, homogenized, and then subjected to ultracentrifugation at 100...


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271257
PNG
(US10059720, Example 72 | US10975091, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC(C)(C)C)c(C)cn1)C(O)=O |r|
Show InChI InChI=1S/C20H34N2O4/c1-13(2)9-17(21)20(25,18(23)24)11-15-10-16(14(3)12-22-15)26-8-7-19(4,5)6/h10,12-13,17,25H,7-9,11,21H2,1-6H3,(H,23,24)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271275
PNG
(US10059720, Example 90 | US10975091, Example 90)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCC(C)(C)CC1)C(O)=O |r|
Show InChI InChI=1S/C20H33N3O3/c1-14(2)11-17(21)20(26,18(24)25)13-15-12-16(5-8-22-15)23-9-6-19(3,4)7-10-23/h5,8,12,14,17,26H,6-7,9-11,13,21H2,1-4H3,(H,24,25)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271275
PNG
(US10059720, Example 90 | US10975091, Example 90)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCC(C)(C)CC1)C(O)=O |r|
Show InChI InChI=1S/C20H33N3O3/c1-14(2)11-17(21)20(26,18(24)25)13-15-12-16(5-8-22-15)23-9-6-19(3,4)7-10-23/h5,8,12,14,17,26H,6-7,9-11,13,21H2,1-4H3,(H,24,25)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
hP-LAP: HEK293 cells forced to transiently express hP-LAP were prepared by lipofection, homogenized, and then subjected to ultracentrifugation at 100...


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271318
PNG
(US10059720, Example 133 | US10975091, Example 133)
Show SMILES N[C@@H](CCC(F)(F)F)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O |r|
Show InChI InChI=1S/C19H23F3N2O4/c20-19(21,22)7-5-16(23)18(27,17(25)26)10-14-13-9-12(4-3-11-1-2-11)28-15(13)6-8-24-14/h6,8-9,11,16,27H,1-5,7,10,23H2,(H,25,26)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271198
PNG
(US10059720, Example 13 | US10975091, Example 13)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCCCC1)C(O)=O |r|
Show InChI InChI=1S/C18H29N3O3/c1-13(2)10-16(19)18(24,17(22)23)12-14-11-15(6-7-20-14)21-8-4-3-5-9-21/h6-7,11,13,16,24H,3-5,8-10,12,19H2,1-2H3,(H,22,23)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271318
PNG
(US10059720, Example 133 | US10975091, Example 133)
Show SMILES N[C@@H](CCC(F)(F)F)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O |r|
Show InChI InChI=1S/C19H23F3N2O4/c20-19(21,22)7-5-16(23)18(27,17(25)26)10-14-13-9-12(4-3-11-1-2-11)28-15(13)6-8-24-14/h6,8-9,11,16,27H,1-5,7,10,23H2,(H,25,26)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271275
PNG
(US10059720, Example 90 | US10975091, Example 90)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCC(C)(C)CC1)C(O)=O |r|
Show InChI InChI=1S/C20H33N3O3/c1-14(2)11-17(21)20(26,18(24)25)13-15-12-16(5-8-22-15)23-9-6-19(3,4)7-10-23/h5,8,12,14,17,26H,6-7,9-11,13,21H2,1-4H3,(H,24,25)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271288
PNG
(US10059720, Example 103 | US10975091, Example 103)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:5.6,3.3,15.15,wD:12.11,5.5,(-7.34,-2.31,;-6,-3.08,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.26,-1.37,;-2,.36,)|
Show InChI InChI=1S/C18H28N2O4S/c1-12-3-5-14(6-4-12)24-15-7-8-20-13(9-15)10-18(23,17(21)22)16(19)11-25-2/h7-9,12,14,16,23H,3-6,10-11,19H2,1-2H3,(H,21,22)/t12-,14-,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271198
PNG
(US10059720, Example 13 | US10975091, Example 13)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCCCC1)C(O)=O |r|
Show InChI InChI=1S/C18H29N3O3/c1-13(2)10-16(19)18(24,17(22)23)12-14-11-15(6-7-20-14)21-8-4-3-5-9-21/h6-7,11,13,16,24H,3-5,8-10,12,19H2,1-2H3,(H,22,23)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
hP-LAP: HEK293 cells forced to transiently express hP-LAP were prepared by lipofection, homogenized, and then subjected to ultracentrifugation at 100...


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271275
PNG
(US10059720, Example 90 | US10975091, Example 90)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCC(C)(C)CC1)C(O)=O |r|
Show InChI InChI=1S/C20H33N3O3/c1-14(2)11-17(21)20(26,18(24)25)13-15-12-16(5-8-22-15)23-9-6-19(3,4)7-10-23/h5,8,12,14,17,26H,6-7,9-11,13,21H2,1-4H3,(H,24,25)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271288
PNG
(US10059720, Example 103 | US10975091, Example 103)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:5.6,3.3,15.15,wD:12.11,5.5,(-7.34,-2.31,;-6,-3.08,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.26,-1.37,;-2,.36,)|
Show InChI InChI=1S/C18H28N2O4S/c1-12-3-5-14(6-4-12)24-15-7-8-20-13(9-15)10-18(23,17(21)22)16(19)11-25-2/h7-9,12,14,16,23H,3-6,10-11,19H2,1-2H3,(H,21,22)/t12-,14-,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130738
PNG
(US8822448, 129)
Show SMILES CCc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CCCCOC)[C@H](C)C1 |r|
Show InChI InChI=1S/C28H39N5O4/c1-4-20-15-25-23(26-24(27(34)30-25)17-29-33(26)21-7-13-37-14-8-21)16-22(20)28(35)32-11-10-31(19(2)18-32)9-5-6-12-36-3/h15-17,19,21H,4-14,18H2,1-3H3,(H,30,34)/t19-/m1/s1
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Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271258
PNG
(US10059720, Example 73 | US10975091, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)c(C)cn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-7.34,-2.31,;-6,-3.08,;-6,-4.62,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;4.67,,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.31,-.98,;-2,.36,)|
Show InChI InChI=1S/C21H34N2O4/c1-13(2)9-19(22)21(26,20(24)25)11-16-10-18(15(4)12-23-16)27-17-7-5-14(3)6-8-17/h10,12-14,17,19,26H,5-9,11,22H2,1-4H3,(H,24,25)/t14-,17-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271277
PNG
(US10059720, Example 92 | US10975091, Example 92)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H](C)Cc2ccccc2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C22H30N2O4/c1-15(2)11-20(23)22(27,21(25)26)14-18-13-19(9-10-24-18)28-16(3)12-17-7-5-4-6-8-17/h4-10,13,15-16,20,27H,11-12,14,23H2,1-3H3,(H,25,26)/t16-,20+,22-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271258
PNG
(US10059720, Example 73 | US10975091, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)c(C)cn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-7.34,-2.31,;-6,-3.08,;-6,-4.62,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;4.67,,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.31,-.98,;-2,.36,)|
Show InChI InChI=1S/C21H34N2O4/c1-13(2)9-19(22)21(26,20(24)25)11-16-10-18(15(4)12-23-16)27-17-7-5-14(3)6-8-17/h10,12-14,17,19,26H,5-9,11,22H2,1-4H3,(H,24,25)/t14-,17-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271277
PNG
(US10059720, Example 92 | US10975091, Example 92)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H](C)Cc2ccccc2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C22H30N2O4/c1-15(2)11-20(23)22(27,21(25)26)14-18-13-19(9-10-24-18)28-16(3)12-17-7-5-4-6-8-17/h4-10,13,15-16,20,27H,11-12,14,23H2,1-3H3,(H,25,26)/t16-,20+,22-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271213
PNG
(US10059720, Example 28 | US10975091, Example 28)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC2(C)CC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C19H30N2O4/c1-13(2)10-16(20)19(24,17(22)23)12-14-11-15(4-8-21-14)25-9-7-18(3)5-6-18/h4,8,11,13,16,24H,5-7,9-10,12,20H2,1-3H3,(H,22,23)/t16-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271190
PNG
(US10059720, Example 6 | US10975091, Example 6)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-7.34,-2.31,;-6,-3.08,;-6,-4.62,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.31,-.98,;-2,.36,)|
Show InChI InChI=1S/C20H32N2O4/c1-13(2)10-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(3)5-7-16/h8-9,11,13-14,16,18,25H,4-7,10,12,21H2,1-3H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))
BDBM130781
PNG
(US8822448, 211)
Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C |r|
Show InChI InChI=1S/C25H30F3N5O2/c1-15-10-21-19(22-20(23(34)30-21)12-29-33(22)14-17-4-3-5-17)11-18(15)24(35)32-9-8-31(16(2)13-32)7-6-25(26,27)28/h10-12,16-17H,3-9,13-14H2,1-2H3,(H,30,34)/t16-/m0/s1
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Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...


US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271260
PNG
(US10059720, Example 75 | US10975091, Example 75)
Show SMILES COCCCCC[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C21H34N2O5/c1-27-13-7-3-6-10-19(22)21(26,20(24)25)15-16-14-18(11-12-23-16)28-17-8-4-2-5-9-17/h11-12,14,17,19,26H,2-10,13,15,22H2,1H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271277
PNG
(US10059720, Example 92 | US10975091, Example 92)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H](C)Cc2ccccc2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C22H30N2O4/c1-15(2)11-20(23)22(27,21(25)26)14-18-13-19(9-10-24-18)28-16(3)12-17-7-5-4-6-8-17/h4-10,13,15-16,20,27H,11-12,14,23H2,1-3H3,(H,25,26)/t16-,20+,22-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
hP-LAP: HEK293 cells forced to transiently express hP-LAP were prepared by lipofection, homogenized, and then subjected to ultracentrifugation at 100...


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271190
PNG
(US10059720, Example 6 | US10975091, Example 6)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-7.34,-2.31,;-6,-3.08,;-6,-4.62,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.31,-.98,;-2,.36,)|
Show InChI InChI=1S/C20H32N2O4/c1-13(2)10-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(3)5-7-16/h8-9,11,13-14,16,18,25H,4-7,10,12,21H2,1-3H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271213
PNG
(US10059720, Example 28 | US10975091, Example 28)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC2(C)CC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C19H30N2O4/c1-13(2)10-16(20)19(24,17(22)23)12-14-11-15(4-8-21-14)25-9-7-18(3)5-6-18/h4,8,11,13,16,24H,5-7,9-10,12,20H2,1-3H3,(H,22,23)/t16-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....


US Patent US10975091 (2021)


BindingDB Entry DOI: 10.7270/Q2FF3WHR
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271260
PNG
(US10059720, Example 75 | US10975091, Example 75)
Show SMILES COCCCCC[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C21H34N2O5/c1-27-13-7-3-6-10-19(22)21(26,20(24)25)15-16-14-18(11-12-23-16)28-17-8-4-2-5-9-17/h11-12,14,17,19,26H,2-10,13,15,22H2,1H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271277
PNG
(US10059720, Example 92 | US10975091, Example 92)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H](C)Cc2ccccc2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C22H30N2O4/c1-15(2)11-20(23)22(27,21(25)26)14-18-13-19(9-10-24-18)28-16(3)12-17-7-5-4-6-8-17/h4-10,13,15-16,20,27H,11-12,14,23H2,1-3H3,(H,25,26)/t16-,20+,22-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271243
PNG
(US10059720, Example 58 | US10975091, Example 58)
Show SMILES CC(C)C[C@@H](C)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1 |r|
Show InChI InChI=1S/C19H32N2O4/c1-12(2)8-14(5)25-16-6-7-21-15(10-16)11-19(24,18(22)23)17(20)9-13(3)4/h6-7,10,12-14,17,24H,8-9,11,20H2,1-5H3,(H,22,23)/t14-,17+,19-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271330
PNG
(US10059720, Example 145 | US10975091, Example 145)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:7.8,5.5,17.17,wD:7.7,14.13,(-8.67,-2.31,;-7.34,-3.08,;-6,-2.31,;-4.67,-3.08,;-3.33,-2.31,;-2,-3.08,;-2,-4.62,;-.67,-2.31,;.1,-.98,;.67,-3.08,;2,-2.31,;2,-.77,;3.33,,;3.33,1.54,;4.67,2.31,;6,1.54,;7.34,2.31,;7.34,3.85,;8.67,4.62,;6,4.62,;4.67,3.85,;4.67,-.77,;4.67,-2.31,;3.33,-3.08,;-1.44,-.98,;-2.92,-1.37,;-.67,.36,)|
Show InChI InChI=1S/C20H32N2O4S/c1-3-10-27-13-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(2)5-7-16/h8-9,11,14,16,18,25H,3-7,10,12-13,21H2,1-2H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271190
PNG
(US10059720, Example 6 | US10975091, Example 6)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-7.34,-2.31,;-6,-3.08,;-6,-4.62,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.31,-.98,;-2,.36,)|
Show InChI InChI=1S/C20H32N2O4/c1-13(2)10-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(3)5-7-16/h8-9,11,13-14,16,18,25H,4-7,10,12,21H2,1-3H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271198
PNG
(US10059720, Example 13 | US10975091, Example 13)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCCCC1)C(O)=O |r|
Show InChI InChI=1S/C18H29N3O3/c1-13(2)10-16(19)18(24,17(22)23)12-14-11-15(6-7-20-14)21-8-4-3-5-9-21/h6-7,11,13,16,24H,3-5,8-10,12,19H2,1-2H3,(H,22,23)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
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