| Reaction Details |
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 | Report a problem with these data |
| Target | Protein disulfide-isomerase |
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| Ligand | BDBM271337 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Insulin reductase assay |
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| IC50 | 2250±n/a nM |
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| Citation |  Flaumenhaft, R; Nag, PP; Pilyugina, T; Pu, J; Dandapani, S; Munoz, B; Dockendorff, C Compounds for use in methods for treating diseases or conditions mediated by protein disulfide isomerase US Patent US10064853 Publication Date 9/4/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein disulfide-isomerase |
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| Name: | Protein disulfide-isomerase |
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| Synonyms: | Cellular thyroid hormone-binding protein | ERBA2L | P4HB | PDI | PDIA1 | PDIA1_HUMAN | PO4DB | Protein Disulfide-Isomerase (PDI) |
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| Type: | Protein |
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| Mol. Mass.: | 57084.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07237 |
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| Residue: | 508 |
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| Sequence: | MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALA
PEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGR
EADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAID
DIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEF
TEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQR
ILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQEL
PEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENI
VIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGD
DDDLEDLEEAEEPDMEEDDDQKAVKDEL
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| BDBM271337 |
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| n/a |
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| Name | BDBM271337 |
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| Synonyms: | US10064853, Compound 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26ClNO5 |
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| Mol. Mass. | 431.909 |
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| SMILES | CCOC(=O)C1(CCOc2ccccc2)CCN(CC1)C(=O)c1ccc(O)c(Cl)c1 |
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| Structure | 
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