Reaction Details |
| Report a problem with these data |
Target | Dihydrofolate reductase |
---|
Ligand | BDBM82109 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Inhibition Assay |
---|
IC50 | 2.3±0.0 nM |
---|
Citation | Ma, X; Woon, RS; Ho, PC; Chui, WK Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates. Chem Biol Drug Des74:322-6 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydrofolate reductase |
---|
Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) |
Type: | Enzyme |
Mol. Mass.: | 21603.71 |
Organism: | Bos taurus (Cattle) |
Description: | P00376 |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
|
|
|
BDBM82109 |
---|
n/a |
---|
Name | BDBM82109 |
Synonyms: | 6,8,10-Traiazaspiro[4.5]deca-6,8-diene-7,9-diamine, Ie | CHEMBL1800937 |
Type | Small organic molecule |
Emp. Form. | C16H23N5O2 |
Mol. Mass. | 317.3861 |
SMILES | NC1=NC2(CCCC2)N(OCCCOc2ccccc2)C(N)=N1 |c:23,t:1| |
Structure |
|