Reaction Details |
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Target | Virion infectivity factor |
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Ligand | BDBM272201 |
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Substrate/Competitor | n/a |
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Meas. Tech. | HIV Integrase Inhibitory Assay |
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Temperature | 298.15±n/a K |
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IC50 | 3.40±n/a nM |
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Comments | extracted |
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Citation | Miyazaki, S; Bessho, Y; Adachi, K; Kawashita, S; Isoshima, H; Oshita, K; Fukuda, S Substituted thiazoles as HIV integrase inhibitors US Patent US10065950 Publication Date 9/4/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Virion infectivity factor |
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Name: | Virion infectivity factor |
Synonyms: | HIV integrase | SOR | VIF_HV1N5 | Virion infectivity factor | inhibitory activity | vif |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 22719.51 |
Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1) |
Description: | P12504 |
Residue: | 192 |
Sequence: | MENRWQVMIVWQVDRMRINTWKRLVKHHMYISRKAKDWFYRHHYESTNPKISSEVHIPLG
DAKLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPDLADQLIHLHYFDCFSESAI
RNTILGRIVSPRCEYQAGHNKVGSLQYLALAALIKPKQIKPPLPSVRKLTEDRWNKPQKT
KGHRGSHTMNGH
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BDBM272201 |
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n/a |
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Name | BDBM272201 |
Synonyms: | US10065950, Example 42 |
Type | Small organic molecule |
Emp. Form. | C22H22F2N4O4S |
Mol. Mass. | 476.496 |
SMILES | COCC1Cn2cc(-c3nnc(Cc4ccc(F)cc4F)s3)c(=O)c(O)c2C(=O)N1C(C)C |
Structure |
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