| Reaction Details |
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 | Report a problem with these data |
| Target | Virion infectivity factor |
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| Ligand | BDBM272259 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HIV Integrase Inhibitory Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 6.40±n/a nM |
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| Comments | extracted |
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| Citation |  Miyazaki, S; Bessho, Y; Adachi, K; Kawashita, S; Isoshima, H; Oshita, K; Fukuda, S Substituted thiazoles as HIV integrase inhibitors US Patent US10065950 Publication Date 9/4/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Virion infectivity factor |
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| Name: | Virion infectivity factor |
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| Synonyms: | HIV integrase | SOR | VIF_HV1N5 | Virion infectivity factor | inhibitory activity | vif |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 22719.51 |
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| Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1) |
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| Description: | P12504 |
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| Residue: | 192 |
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| Sequence: | MENRWQVMIVWQVDRMRINTWKRLVKHHMYISRKAKDWFYRHHYESTNPKISSEVHIPLG
DAKLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPDLADQLIHLHYFDCFSESAI
RNTILGRIVSPRCEYQAGHNKVGSLQYLALAALIKPKQIKPPLPSVRKLTEDRWNKPQKT
KGHRGSHTMNGH
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| BDBM272259 |
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| n/a |
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| Name | BDBM272259 |
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| Synonyms: | US10065950, Example 101 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23F2N3O5S2 |
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| Mol. Mass. | 523.573 |
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| SMILES | CC(C)N1CC(CS(C)(=O)=O)n2cc(-c3ncc(Cc4ccc(F)cc4F)s3)c(=O)c(O)c2C1=O |
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| Structure | 
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