| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM82437 |
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| Substrate/Competitor | n/a |
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| Ki | 360±n/a nM |
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| Comments | PDSP_1088 |
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| Citation |  Cusack, B; Nelson, A; Richelson, E Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl)114:559-65 (1994) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55808.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
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| Residue: | 487 |
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| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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| BDBM82437 |
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| n/a |
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| Name | BDBM82437 |
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| Synonyms: | CAS_23047-25-8 | Lofepramine | NSC_3947 | US8629135, SW-06 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27ClN2O |
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| Mol. Mass. | 418.958 |
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| SMILES | CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1 |
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| Structure | 
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