| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor A |
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| Ligand | BDBM82258 |
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| Substrate/Competitor | n/a |
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| Ki | 12.1±n/a nM |
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| Comments | PDSP_1089 |
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| Citation |  Keiser, JA; Ryan, MJ; Panek, RL; Hodges, JC; Sircar, I Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist. J Pharmacol Exp Ther272:963-9 (1995) [PubMed] |
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| More Info.: | Get all data from this article |
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| Type-1 angiotensin II receptor A |
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| Name: | Type-1 angiotensin II receptor A |
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| Synonyms: | AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40910.53 |
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| Organism: | RAT |
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| Description: | ANGIOTENSIN AT1 AGTR1 RAT::P25095 |
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| Residue: | 359 |
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| Sequence: | MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
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| BDBM82258 |
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| n/a |
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| Name | BDBM82258 |
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| Synonyms: | CAS_114798-26-4 | Losartan | NSC_3961 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23ClN6O |
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| Mol. Mass. | 422.911 |
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| SMILES | CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |
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| Structure | 
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