Ki Summary

Reaction Details

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Target

Beta-lactamase

Ligand

BDBM83241

Substrate/Competitor

n/a

Meas. Tech.

Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA)

IC50

7680±n/a nM

Citation

PubChem, PC Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Assay Method

Beta-lactamase

Name:

Beta-lactamase

Synonyms:

Beta lactamase

Type:

Enzyme Catalytic Domain

Mol. Mass.:

31513.38

Organism:

Pseudomonas aeruginosa

Description:

gi_114881106

Residue:

286

Sequence:

MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW

BDBM83241

n/a

Name

BDBM83241

Synonyms:

(4E)-4-[(2Z)-2-(5,7-dibromo-8-hydroxy-1H-quinolin-2-ylidene)ethylidene]-2-methoxy-1-cyclohexa-2,5-dienone | (4E)-4-[(2Z)-2-(5,7-dibromo-8-hydroxy-1H-quinolin-2-ylidene)ethylidene]-2-methoxy-cyclohexa-2,5-dien-1-one | (4E)-4-[(2Z)-2-(5,7-dibromo-8-hydroxy-1H-quinolin-2-ylidene)ethylidene]-2-methoxycyclohexa-2,5-dien-1-one | (4E)-4-[(2Z)-2-[5,7-bis(bromanyl)-8-oxidanyl-1H-quinolin-2-ylidene]ethylidene]-2-methoxy-cyclohexa-2,5-dien-1-one | MLS000736745 | SMR000528308 | cid_16682521

Type

Small organic molecule

Emp. Form.

C18H13Br2NO3

Mol. Mass.

451.109

SMILES

COc1cc(C=Cc2ccc3c(Br)cc(Br)c(O)c3n2)ccc1O |w:6.6|

Structure