| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM67449 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) |
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| IC50 | 3479±n/a nM |
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| Citation |  PubChem, PC Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | Beta lactamase |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 31513.38 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | gi_114881106 |
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| Residue: | 286 |
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| Sequence: | MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
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|
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| BDBM67449 |
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| n/a |
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| Name | BDBM67449 |
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| Synonyms: | 2-(2,4-diketo-1,3-diazaspiro[4.5]decan-3-yl)acetic acid [2-keto-4-(trifluoromethyl)chromen-7-yl] ester | 2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetic acid [2-oxo-4-(trifluoromethyl)-1-benzopyran-7-yl] ester | MLS001141678 | SMR000705589 | [2-oxidanylidene-4-(trifluoromethyl)chromen-7-yl] 2-[2,4-bis(oxidanylidene)-1,3-diazaspiro[4.5]decan-3-yl]ethanoate | [2-oxo-4-(trifluoromethyl)chromen-7-yl] 2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetate | cid_16281348 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17F3N2O6 |
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| Mol. Mass. | 438.354 |
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| SMILES | FC(F)(F)c1cc(=O)oc2cc(OC(=O)CN3C(=O)NC4(CCCCC4)C3=O)ccc12 |
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| Structure | 
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