Ki Summary

Reaction Details

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Target

Orotidine 5'-phosphate decarboxylase

Ligand

BDBM67847

Substrate/Competitor

n/a

Meas. Tech.

Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter

EC50

>59630±n/a nM

Citation

PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Assay Method

Orotidine 5'-phosphate decarboxylase

Name:

Orotidine 5'-phosphate decarboxylase

Synonyms:

FXN frataxin | PYRF_ASPNG | pyrA | pyrG

Type:

Enzyme Catalytic Domain

Mol. Mass.:

30195.13

Organism:

Aspergillus niger

Description:

gi_2395

Residue:

277

Sequence:

MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAV
IKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHI
INCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKY
KNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGA
DFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN

BDBM67847

n/a

Name

BDBM67847

Synonyms:

4-(4-Chloro-phenyl)-5-cyano-2-methyl-6-(thiazol-2-ylcarbamoylmethylsulfanyl)-1,4-dihydro-pyridine-3-ca rboxylic acid allyl ester | 4-(4-chlorophenyl)-5-cyano-2-methyl-6-[[2-oxo-2-(2-thiazolylamino)ethyl]thio]-1,4-dihydropyridine-3-carboxylic acid prop-2-enyl ester | 4-(4-chlorophenyl)-5-cyano-6-[[2-keto-2-(thiazol-2-ylamino)ethyl]thio]-2-methyl-1,4-dihydropyridine-3-carboxylic acid allyl ester | MLS000555475 | SMR000147192 | cid_3409527 | prop-2-enyl 4-(4-chlorophenyl)-5-cyano-2-methyl-6-[2-oxidanylidene-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl-1,4-dihydropyridine-3-carboxylate | prop-2-enyl 4-(4-chlorophenyl)-5-cyano-2-methyl-6-[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl-1,4-dihydropyridine-3-carboxylate

Type

Small organic molecule

Emp. Form.

C22H19ClN4O3S2

Mol. Mass.

486.994

SMILES

CC1=C(C(C(C#N)C(SCC(=O)Nc2nccs2)=N1)c1ccc(Cl)cc1)C(=O)OCC=C |c:18,t:1|

Structure