Ki Summary

Reaction Details

Report a problem with these data

Target

Orotidine 5'-phosphate decarboxylase

Ligand

BDBM83835

Substrate/Competitor

n/a

Meas. Tech.

Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter

EC50

>59638±n/a nM

Citation

PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Assay Method

Orotidine 5'-phosphate decarboxylase

Name:

Orotidine 5'-phosphate decarboxylase

Synonyms:

FXN frataxin | PYRF_ASPNG | pyrA | pyrG

Type:

Enzyme Catalytic Domain

Mol. Mass.:

30195.13

Organism:

Aspergillus niger

Description:

gi_2395

Residue:

277

Sequence:

MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAV
IKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHI
INCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKY
KNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGA
DFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN

BDBM83835

n/a

Name

BDBM83835

Synonyms:

2-amino-4-[(4-cyanobenzyl)thio]-1-(4-phenylthiazol-2-yl)-3-azaspiro[5.5]undeca-2,4-diene-5-carbonitrile | 2-amino-4-[(4-cyanophenyl)methylsulfanyl]-1-(4-phenyl-1,3-thiazol-2-yl)-3-azaspiro[5.5]undeca-2,4-diene-5-carbonitrile | 2-amino-4-[(4-cyanophenyl)methylthio]-1-(4-phenyl-2-thiazolyl)-3-azaspiro[5.5]undeca-2,4-diene-5-carbonitrile | 2-azanyl-4-[(4-cyanophenyl)methylsulfanyl]-1-(4-phenyl-1,3-thiazol-2-yl)-3-azaspiro[5.5]undeca-2,4-diene-5-carbonitrile | MLS002634876 | SMR000154115 | cid_4840090

Type

Small organic molecule

Emp. Form.

C28H25N5S2

Mol. Mass.

495.662

SMILES

NC1=NC(SCc2ccc(cc2)C#N)=C(C#N)C2(CCCCC2)C1c1nc(cs1)-c1ccccc1 |t:1,14|

Structure