Reaction Details |
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Target | Alpha-1B adrenergic receptor |
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Ligand | BDBM84440 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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Ki | 225±0.0 nM |
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Citation | Hendrix, JA; Shimshock, SJ; Shutske, GM; Tomer, JD; Kapples, KJ; Palermo, MG; Corbett, TJ; Vargas, HM; Kafka, S; Brooks, KM; Laws-Ricker, L; Lee, DK; de Lannoy, I; Bordeleau, M; Rizkalla, G; Owolabi, J; Kamboj, RK Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent, selective, and orally active human dopamine D4 receptor antagonists. Chembiochem3:999-1009 (2002) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1B adrenergic receptor |
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Name: | Alpha-1B adrenergic receptor |
Synonyms: | ADA1B_RAT | Adra1b | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha adrenergic receptor 1A and 1B | Alpha-1 Adrenergic Receptor | Alpha-1Adrenoceptor | Alpha-1B adrenergic receptor | Alpha-1B adrenoreceptor | adrenergic Alpha1B |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 56606.71 |
Organism: | Rattus norvegicus (rat) |
Description: | Receptor binding assays were performed using rat cortical membranes. |
Residue: | 515 |
Sequence: | MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFM
RILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLP
SASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESP
GTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
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BDBM84440 |
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n/a |
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Name | BDBM84440 |
Synonyms: | Isoindoline, 7 | Isoindoline, 8 | Isoindoline, 9 |
Type | Small organic molecule |
Emp. Form. | C23H26FN3O2 |
Mol. Mass. | 395.4698 |
SMILES | OCC(CN1Cc2ccccc2C1)N1CCC(CC1)c1noc2cc(F)ccc12 |
Structure |
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