| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-mannosidase 2 |
|---|
| Ligand | BDBM84471 |
|---|
| Substrate/Competitor | n/a |
|---|
| pH | 5.6±0 |
|---|
| Temperature | 310.15±0 K |
|---|
| Ki | 8.1e+3±n/a nM |
|---|
| Citation |  Li, B; Kawatkar, SP; George, S; Strachan, H; Woods, RJ; Siriwardena, A; Moremen, KW; Boons, GJ Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies. Chembiochem5:1220-7 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info |
|---|
| |
| Alpha-mannosidase 2 |
|---|
| Name: | Alpha-mannosidase 2 |
|---|
| Synonyms: | Alpha-mannosidase 2A1 | Golgi alpha-mannosidase II | Lysosomal acid alpha-mannosidase | MA2A1_HUMAN | MAN2A1 | MANA2 | Mannosidase alpha class 2A member 1 | Mannosidase alpha class 2B member 1 | Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 131156.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16706 |
|---|
| Residue: | 1144 |
|---|
| Sequence: | MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLER
LLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFAS
QSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGW
LKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIEN
GQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYL
LNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTC
GPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLL
APLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRD
KGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAH
KYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIG
NSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDR
ISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKI
LESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMT
KEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTC
FFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQ
IQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQ
DDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPM
ANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFS
SKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFR
IQLR
|
|
|
|---|
| BDBM84471 |
|---|
| n/a |
|---|
| Name | BDBM84471 |
|---|
| Synonyms: | Aminocyclopentitetrol, 2d |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H16ClNO4 |
|---|
| Mol. Mass. | 273.713 |
|---|
| SMILES | O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(Cl)cc2)[C@H]1O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
