| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-mannosidase 2 |
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| Ligand | BDBM50078117 |
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| Substrate/Competitor | n/a |
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| pH | 5.6±0 |
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| Temperature | 310.15±0 K |
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| Ki | 9e+1±n/a nM |
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| Citation |  Li, B; Kawatkar, SP; George, S; Strachan, H; Woods, RJ; Siriwardena, A; Moremen, KW; Boons, GJ Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies. Chembiochem5:1220-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info |
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| Alpha-mannosidase 2 |
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| Name: | Alpha-mannosidase 2 |
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| Synonyms: | Alpha-mannosidase 2A1 | Golgi alpha-mannosidase II | Lysosomal acid alpha-mannosidase | MA2A1_HUMAN | MAN2A1 | MANA2 | Mannosidase alpha class 2A member 1 | Mannosidase alpha class 2B member 1 | Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase |
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| Type: | Protein |
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| Mol. Mass.: | 131156.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16706 |
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| Residue: | 1144 |
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| Sequence: | MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLER
LLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFAS
QSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGW
LKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIEN
GQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYL
LNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTC
GPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLL
APLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRD
KGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAH
KYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIG
NSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDR
ISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKI
LESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMT
KEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTC
FFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQ
IQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQ
DDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPM
ANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFS
SKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFR
IQLR
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| BDBM50078117 |
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| n/a |
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| Name | BDBM50078117 |
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| Synonyms: | (1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL | (1R,2R,3R,4S,5R)-4-Amino-5-methylsulfanyl-cyclopentane-1,2,3-triol | CHEMBL9623 | Mannostatin A, 1 | Mannostatin A, 1a |
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| Type | Small organic molecule |
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| Emp. Form. | C6H13NO3S |
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| Mol. Mass. | 179.237 |
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| SMILES | CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O |
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| Structure | 
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