Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProgonadoliberin-1
LigandBDBM84723
Substrate/Competitorn/a
Ki 3.24±n/a nM
CommentsPDSP_186
Citation Haviv, FFitzpatrick, TDSwenson, RENichols, CJMort, NABush, ENDiaz, GBammert, GNguyen, ARhutasel, NS Effect of N-methyl substitution of the peptide bonds in luteinizing hormone-releasing hormone agonists. J Med Chem36:363-9 (1993) [PubMed]  Article
More Info.:Get all data from this article
 
Progonadoliberin-1
Name:Progonadoliberin-1
Synonyms:GON1_RAT | Gnrh | Gnrh1 | Luteinizing Hormone-Releasing Hormone LHRH | Progonadoliberin-1
Type:Enzyme Catalytic Domain
Mol. Mass.:10497.39
Organism:RAT
Description:Luteinizing Hormone-Releasing Hormone LHRH 0 RAT::P07490
Residue:92
Sequence:
METIPKLMAAVVLLTVCLEGCSSQHWSYGLRPGGKRNTEHLVDSFQEMGKEEDQMAEPQN
FECTVHWPRSPLRDLRGALERLIEEEAGQKKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM84723
n/a
NameBDBM84723
Synonyms:leuprolide 3NMe1Nal
TypeSmall organic molecule
Emp. Form.C62H87N15O12
Mol. Mass.1234.4475
SMILESCCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)N(C)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r,wU:51.55,73.84,83.87,31.36,5.4,wD:57.72,39.49,23.28,12.20,(10.22,12.44,;9.73,11.04,;10.69,9.91,;10.16,8.49,;11.09,7.36,;8.69,8.25,;7.58,9.33,;6.25,8.6,;6.47,7.14,;8.01,6.89,;8.69,5.56,;10.34,5.13,;7.76,4.7,;8.05,3.19,;9.4,2.76,;10.56,3.77,;11.98,3.34,;13.07,4.34,;14.52,3.91,;12.73,5.81,;6.36,5.25,;5.17,4.27,;3.75,4.73,;5.43,2.76,;6.79,2.3,;7.11,.79,;6.64,-.49,;8.54,.28,;4.27,1.76,;2.87,2.26,;2.59,3.77,;1.73,1.23,;1.97,-.25,;3.45,-.72,;3.77,-2.23,;4.1,.15,;.26,1.68,;-.83,.68,;-2.3,1.12,;-.5,-.83,;.97,-1.29,;1.33,-2.76,;.22,-3.83,;.66,-5.34,;2.12,-5.74,;2.48,-7.21,;3.27,-4.67,;2.81,-3.11,;-1.58,-1.87,;-2.98,-1.43,;-3.37,.08,;-4.09,-2.51,;-5.56,-2.12,;-6.7,-3.19,;-3.76,-3.99,;-4.84,-5.02,;-6.31,-4.63,;-4.45,-6.49,;-2.94,-6.89,;-2.63,-8.53,;-1.14,-8.92,;-.74,-10.41,;-1.83,-11.5,;-3.32,-11.1,;-4.41,-12.19,;-5.89,-11.79,;-6.29,-10.3,;-5.2,-9.22,;-3.72,-9.61,;-5.56,-7.56,;-5.96,-9.05,;-7.01,-7.21,;-7.41,-5.74,;-8.1,-8.33,;-9.59,-7.89,;-9.99,-6.42,;-11.44,-5.87,;-11.3,-4.34,;-9.79,-3.94,;-9,-5.27,;-7.71,-9.82,;-8.81,-10.93,;-8.46,-12.44,;-10.37,-10.57,;-10.93,-9.1,;-12.5,-9.1,;-12.97,-10.64,;-14.52,-11.2,;-11.66,-11.59,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: