| Reaction Details |
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 | Report a problem with these data |
| Target | Anoctamin-1 |
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| Ligand | BDBM50239462 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1666071 (CHEMBL4015867) |
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| IC50 | 840±n/a nM |
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| Citation |  Truong, EC; Phuan, PW; Reggi, AL; Ferrera, L; Galietta, LJV; Levy, SE; Moises, AC; Cil, O; Diez-Cecilia, E; Lee, S; Verkman, AS; Anderson, MO Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). J Med Chem60:4626-4635 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Anoctamin-1 |
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| Name: | Anoctamin-1 |
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| Synonyms: | ANO1 | ANO1_HUMAN | DOG1 | Discovered on gastrointestinal stromal tumors protein 1 | ORAOV2 | Oral cancer overexpressed protein 2 | TAOS2 | TMEM16A | Transmembrane protein 16A | Tumor-amplified and overexpressed sequence 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 114103.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_828184 |
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| Residue: | 986 |
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| Sequence: | MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRR
KVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYH
EDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK
MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSF
FDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKL
LYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATM
DENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWA
ATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHI
PEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIY
RISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEK
SFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMEL
CIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLE
PFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRA
KDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNV
SDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNL
VMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPC
NHHNTKACPDSLGSPAPSHAYHGGVL
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| BDBM50239462 |
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| n/a |
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| Name | BDBM50239462 |
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| Synonyms: | CHEMBL4066286 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16ClF3N2O2S |
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| Mol. Mass. | 416.845 |
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| SMILES | Fc1ccc(NC(=O)c2c(NC(=O)C(F)(F)Cl)sc3CCCCCc23)cc1 |
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| Structure | 
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