| Reaction Details |
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 | Report a problem with these data |
| Target | Anoctamin-2 |
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| Ligand | BDBM50239459 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1666073 (CHEMBL4015869) |
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| IC50 | 400±n/a nM |
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| Citation |  Truong, EC; Phuan, PW; Reggi, AL; Ferrera, L; Galietta, LJV; Levy, SE; Moises, AC; Cil, O; Diez-Cecilia, E; Lee, S; Verkman, AS; Anderson, MO Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). J Med Chem60:4626-4635 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Anoctamin-2 |
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| Name: | Anoctamin-2 |
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| Synonyms: | ANO2 | ANO2_HUMAN | Anoctamin-2 | C12orf3 | TMEM16B | Transmembrane protein 16B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 113968.03 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117372 |
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| Residue: | 1003 |
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| Sequence: | MATPGPRDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPC
GGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPG
HSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENK
SQGSIFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPR
VPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGI
NSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKI
GLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDY
WNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEE
RAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFA
SILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIY
GAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVF
DGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETD
SAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRL
DAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSH
NGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYW
FILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKL
MDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV
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| BDBM50239459 |
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| n/a |
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| Name | BDBM50239459 |
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| Synonyms: | CHEMBL4074929 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19BrF2N2O2S |
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| Mol. Mass. | 457.332 |
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| SMILES | Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Br)sc2CCCCCc12 |
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| Structure | 
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