Reaction Details |
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Target | Diacylglycerol O-acyltransferase 1 |
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Ligand | BDBM50239484 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1666098 (CHEMBL4015894) |
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IC50 | 23±n/a nM |
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Citation | Nakajima, K; Chatelain, R; Clairmont, KB; Commerford, R; Coppola, GM; Daniels, T; Forster, CJ; Gilmore, TA; Gong, Y; Jain, M; Kanter, A; Kwak, Y; Li, J; Meyers, CD; Neubert, AD; Szklennik, P; Tedesco, V; Thompson, J; Truong, D; Yang, Q; Hubbard, BK; Serrano-Wu, MH Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans. J Med Chem60:4657-4664 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol O-acyltransferase 1 |
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Name: | Diacylglycerol O-acyltransferase 1 |
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
Type: | Protein |
Mol. Mass.: | 55297.82 |
Organism: | Homo sapiens (Human) |
Description: | O75907 |
Residue: | 488 |
Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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BDBM50239484 |
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n/a |
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Name | BDBM50239484 |
Synonyms: | CHEMBL4103025 |
Type | Small organic molecule |
Emp. Form. | C22H14Cl2N4O2 |
Mol. Mass. | 437.278 |
SMILES | COc1ccc(cc1)-c1nnc(o1)-c1ccc2nc([nH]c2c1)-c1c(Cl)cccc1Cl |
Structure |
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