Reaction Details |
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Target | Dual specificity protein kinase CLK1/CLK4 |
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Ligand | BDBM50239782 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1667085 (CHEMBL4016881) |
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IC50 | >20000±n/a nM |
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Citation | ElHady, AK; Abdel-Halim, M; Abadi, AH; Engel, M Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins. J Med Chem60:5377-5391 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity protein kinase CLK1/CLK4 |
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Name: | Dual specificity protein kinase CLK1/CLK4 |
Synonyms: | n/a |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1667082 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Dual specificity protein kinase CLK4 |
Synonyms: | CDC-like kinase 4 | CLK4 | CLK4_HUMAN | Dual specificity protein kinase CLK1/CLK4 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 57522.53 |
Organism: | Homo sapiens (Human) |
Description: | gi_10190706 |
Residue: | 481 |
Sequence: | MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR
SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH
CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK
K
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Component 2 |
Name: | Dual specificity protein kinase CLK1 |
Synonyms: | CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1 |
Type: | Protein |
Mol. Mass.: | 57322.21 |
Organism: | Homo sapiens (Human) |
Description: | P49759 |
Residue: | 484 |
Sequence: | MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
KKSI
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BDBM50239782 |
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n/a |
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Name | BDBM50239782 |
Synonyms: | CHEMBL4082113 |
Type | Small organic molecule |
Emp. Form. | C18H16FNO2S |
Mol. Mass. | 329.389 |
SMILES | COc1ccc2sc(cc2c1)C(=O)N(C)Cc1cccc(F)c1 |
Structure |
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