| Reaction Details |
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 | Report a problem with these data |
| Target | Bile acid receptor |
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| Ligand | BDBM10894 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1669525 (CHEMBL4019413) |
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| EC50 | 1400±n/a nM |
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| Citation |  Schmidt, J; Rotter, M; Weiser, T; Wittmann, S; Weizel, L; Kaiser, A; Heering, J; Goebel, T; Angioni, C; Wurglics, M; Paulke, A; Geisslinger, G; Kahnt, A; Steinhilber, D; Proschak, E; Merk, D A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis. J Med Chem60:7703-7724 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bile acid receptor |
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| Name: | Bile acid receptor |
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| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor |
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| Type: | Nuclear Receptor |
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| Mol. Mass.: | 55916.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96RI1 |
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| Residue: | 486 |
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| Sequence: | MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
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| BDBM10894 |
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| n/a |
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| Name | BDBM10894 |
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| Synonyms: | 4-(4-tert-Butylphenylcarboxamidomethyl)benzenesulfonamide | 4-tert-butyl-N-[(4-sulfamoylphenyl)methyl]benzamide | aromatic/heteroaromatic sulfonamide 28 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N2O3S |
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| Mol. Mass. | 346.444 |
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| SMILES | CC(C)(C)c1ccc(cc1)C(=O)NCc1ccc(cc1)S(N)(=O)=O |
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| Structure | 
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