Ki Summary

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Target

4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming)

Ligand

BDBM50187723

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1669774 (CHEMBL4019662)

IC50

0.490000±n/a nM

Citation

Ni, S; Wei, H; Li, B; Chen, F; Liu, Y; Chen, W; Xu, Y; Qiu, X; Li, X; Lu, Y; Liu, W; Hu, L; Lin, D; Wang, M; Zheng, X; Mao, F; Zhu, J; Lan, L; Li, J Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo. J Med Chem60:8145-8159 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming)

Name:

4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming)

Synonyms:

4,4'-diapophytoene desaturase | CRTN_STAAE | Dehydrosqualene desaturase | Diapophytoene desaturase | crtN

Type:

PROTEIN

Mol. Mass.:

56731.85

Organism:

Staphylococcus aureus (strain Newman)

Description:

ChEMBL_116799

Residue:

502

Sequence:

MKIAVIGAGVTGLAAAARIASQGHEVTIFEKNNNVGGRMNQLKKDGFTFDMGPTIVMMPD
VYKDVFTACGKNYEDYIELRQLRYIYDVYFDHDDRITVPTDLAELQQMLESIEPGSTHGF
MSFLTDVYKKYEIARRYFLERTYRKPSDFYNMTSLVQGAKLKTLNHADQLIEHYIDNEKI
QKLLAFQTLYIGIDPKRGPSLYSIIPMIEMMFGVHFIKGGMYGMAQGLAQLNKDLGVNIE
LNAEIEQIIIDPKFKRADAIKVNGDIRKFDKILCTADFPSVAESLMPDFAPIKKYPPHKI
ADLDYSCSAFLMYIGIDIDVTDQVRLHNVIFSDDFRGNIEEIFEGRLSYDPSIYVYVPAV
ADKSLAPEGKTGIYVLMPTPELKTGSGIDWSDEALTQQIKEIIYRKLATIEVFEDIKSHI
VSETIFTPNDFEQTYHAKFGSAFGLMPTLAQSNYYRPQNVSRDYKDLYFAGASTHPGAGV
PIVLTSAKITVDEMIKDIERGV

BDBM50187723

n/a

Name

BDBM50187723

Synonyms:

CHEMBL3827961

Type

Small organic molecule

Emp. Form.

C23H30ClNO

Mol. Mass.

371.943

SMILES

Cl.COc1ccc(\C=C\CN(C)Cc2ccc3CCCCCc3c2)cc1

Structure