| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Substance-P receptor |
|---|
| Ligand | BDBM50002455 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_208650 |
|---|
| IC50 | 790±n/a nM |
|---|
| Citation |  Lawrence, KB; Venepalli, BR; Appell, KC; Goswami, R; Logan, ME; Tomczuk, BE; Yanni, JM Synthesis and substance P antagonist activity of naphthimidazolium derivatives. J Med Chem35:1273-9 (1992) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Substance-P receptor |
|---|
| Name: | Substance-P receptor |
|---|
| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 46371.54 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor. |
|---|
| Residue: | 407 |
|---|
| Sequence: | MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAH
KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTIST
VVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
|
|
|
|---|
| BDBM50002455 |
|---|
| n/a |
|---|
| Name | BDBM50002455 |
|---|
| Synonyms: | 10-Ethyl-1-[2-(1,3,3-trimethyl-1,3-dihydro-indol-2-ylidene)-ethylidene]-1,2,3,10-tetrahydro-10-aza-3a-azonia-pentaleno[1,2-b]naphthalene; iodide | CHEMBL280339 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H30N3 |
|---|
| Mol. Mass. | 420.5681 |
|---|
| SMILES | CCn1c2C(CC[n+]2c2cc3ccccc3cc12)=C\C=C1/N(C)c2ccccc2C1(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
