Reaction Details |
| Report a problem with these data |
Target | Substance-P receptor |
---|
Ligand | BDBM50002460 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_208650 |
---|
IC50 | 310±n/a nM |
---|
Citation | Lawrence, KB; Venepalli, BR; Appell, KC; Goswami, R; Logan, ME; Tomczuk, BE; Yanni, JM Synthesis and substance P antagonist activity of naphthimidazolium derivatives. J Med Chem35:1273-9 (1992) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Substance-P receptor |
---|
Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46371.54 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor. |
Residue: | 407 |
Sequence: | MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAH
KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTIST
VVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
|
|
|
BDBM50002460 |
---|
n/a |
---|
Name | BDBM50002460 |
Synonyms: | 1,3-Diethyl-2-[3-(3-ethyl-3H-benzooxazol-2-ylidene)-propenyl]-3H-naphtho[2,3-d]imidazol-1-ium; iodide | CHEMBL23360 |
Type | Small organic molecule |
Emp. Form. | C27H28N3O |
Mol. Mass. | 410.5302 |
SMILES | CCN1\C(Oc2ccccc12)=C/C=C/c1n(CC)c2cc3ccccc3cc2[n+]1CC |
Structure |
|