| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50002464 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_208650 |
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| IC50 | 310±n/a nM |
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| Citation |  Lawrence, KB; Venepalli, BR; Appell, KC; Goswami, R; Logan, ME; Tomczuk, BE; Yanni, JM Synthesis and substance P antagonist activity of naphthimidazolium derivatives. J Med Chem35:1273-9 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46371.54 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor. |
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| Residue: | 407 |
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| Sequence: | MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAH
KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTIST
VVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
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| BDBM50002464 |
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| n/a |
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| Name | BDBM50002464 |
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| Synonyms: | 10-Ethyl-1-[2-(1,1,3-trimethyl-1,3-dihydro-benzo[e]indol-2-ylidene)-ethylidene]-1,2,3,10-tetrahydro-10-aza-3a-azonia-pentaleno[1,2-b]naphthalene; iodide | CHEMBL24818 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H34N3 |
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| Mol. Mass. | 484.6533 |
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| SMILES | CCn1c2C(CC(C)[n+]2c2cc3ccccc3cc12)=C\C=C1/N(C)c2ccc3ccccc3c2C1(C)C |
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| Structure | 
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